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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Respiratory scleroma: A clinicopathologic study of 51 cases from Guatemala

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Mariz, Bruno A. L. A. [1] ; Sanchez-Romero, Celeste [1, 2] ; Romanach, Mario J. [3] ; de Almeida, Oslei P. [1] ; Carlos, Roman [4]
Total Authors: 5
[1] Univ Estadual Campinas, Piracicaba Dent Sch, Dept Oral Diag, Piracicaba - Brazil
[2] Univ Republica, Fac Dent, Mol Pathol Area, Montevideo - Uruguay
[3] Fed Univ Rio de Janeiro UFRJ, Dept Oral Diag & Pathol, Rio De Janeiro - Brazil
[4] Ctr Clin Cabeza & Cuello, Guatemala City - Guatemala
Total Affiliations: 4
Document type: Journal article
Source: ORAL DISEASES; v. 26, n. 3, p. 670-676, APR 2020.
Web of Science Citations: 0

Objectives To evaluate clinical and pathologically cases of respiratory scleroma diagnosed in a 30-year period in Guatemala. Material and methods Fifty-one cases of respiratory scleroma diagnosed from 1988 to 2018 in a single pathology service in Guatemala were confirmed using Warthin-Starry staining. Immunohistochemical reactions against CD68, LCA, CD20, CD3, and CD138 were performed to illustrate the inflammatory infiltrate. Scanning electron microscopy (SEM) was performed to illustrate bacteria morphology. Results All 51 cases affected patients from poor areas of Guatemala, particularly women (66.7%), with a mean age of 31 years (range 7-66 years). Nose was affected in most cases (96.1%). Other sites involved included pharynx, larynx, palate, maxillary sinuses, and upper lip. Depending on the stage, the disease manifested as ulcerations, nasal deformities, or laryngeal stenosis. Nasal obstruction, epistaxis, dysphonia, fetid discharge, and pain were the main symptoms. Mikulicz cells (CD68+) in a plasma cell-rich inflammatory background (CD138+, CD20+, CD3+/-) were the typical microscopic presentation. In SEM, each macrophagic vacuole contained few to dozens of Klebsiella rhinoscleromatis diplobacilli. Treatment consisted of long-term trimethoprim and sulfamethoxazole, with adequate control of disease. Conclusion Respiratory scleroma is a rare infectious disease affecting the upper respiratory tract, in poor regions of the world, including Guatemala. (AU)

FAPESP's process: 18/24715-2 - FGF-2, FGFR-1, PI3K, Akt and COX-2 expression in Oral Leucoplakia, primary and metastatic Oral Squamous Cell Carcinoma
Grantee:Bruno Augusto Linhares Almeida Mariz
Support Opportunities: Scholarships in Brazil - Doctorate