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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Functional and metabolic imaging in transthoracic biopsies guided by computed tomography

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Zurstrassen, Charles E. [1] ; Tyng, Chiang J. [1] ; Guimaraes, Marcos D. [1] ; Barbosa, Paula N. V. P. [1] ; Pinto, Clovis A. L. [1] ; Bitencourt, Almir G. V. [1] ; Gross, Jeffersson L. [1] ; Lima, Eduardo N. P. [1] ; Cavalcante, Aline C. B. S. [1] ; Matushita Junior, Joao P. K. [1] ; Chojniak, Rubens [1]
Total Authors: 11
[1] AC Camargo Canc Ctr, R Prof Antonio Prudente 211, BR-01509010 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: EUROPEAN RADIOLOGY; v. 30, n. 4, p. 2041-2048, APR 2020.
Web of Science Citations: 0

Objectives CT-guided biopsy of indeterminate lung lesions sometimes provides insufficient histological results due to tumor necrosis. Functional and metabolic methods such as DWI-MR and PET-CT may help by directing sample collection to a lesion area of greater biological representativeness. The objective is to evaluate the histopathological results based on findings on ADC and SUV levels in lung lesions suspected for primary cancer. Methods Tissue samples were evaluated after undergoing biopsies guided by either DWI-MR or PET-CT findings. In each patient, sample collection from two lesion areas was guided by local ADC and SUV. Values were used to define areas of low vs. high suspicion for cancer. Results Patients who underwent DWI-MR had median lesion size of 78.0 mm. Areas of higher suspicion (HSA) had a median ADC of 1.1 x 10(-3) mm(2)/s, while areas of lower suspicion (LSA) had median ADC of 1.8 x 10(-3) mm(2)/s (p = 0.0001). All HSA samples and 71.43% of LSA samples were positive for cancer (p = 0.0184). Patients who performed PET-CT had median lesion size of 61.0 mm. Median SUV was 7.1 for HSA and 3.9 for LSA (p = 0.0002). Positivity for cancer was observed in 76.9% of samples for both HSA and LSA (p = 0.0522). Conclusion Use of DWI-MR and PET-CT showed that tumors are functional and metabolically heterogeneous and that this heterogeneity has implications for histopathological diagnosis. (AU)

FAPESP's process: 13/15143-1 - Evaluation of functional imaging via di PET/CT and DW-MRI in biopsies guided transthoracic CT
Grantee:Rubens Chojniak
Support Opportunities: Regular Research Grants