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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Green propolis increases myeloid suppressor cells and CD4(+) Foxp3(+) cells and reduces Th2 inflammation in the lungs after allergen exposure

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Pineros, Annie R. [1] ; de Lima, Mikhael H. F. [1] ; Rodrigues, Tamara [1] ; Gembre, Ana Flavia [1] ; Bertolini, Thais B. [1] ; Fonseca, Miriam D. [2] ; Berretta, Andresa A. [3] ; Ramalho, Leandra N. Z. [4] ; Cunha, Fernando Q. [2] ; Hori, Juliana I. [3] ; Bonato, Vania L. D. [1]
Total Authors: 11
[1] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Biochem & Immunol, Basic & Appl Immunol Program, Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pharmacol, Ribeirao Preto, SP - Brazil
[3] Apis Flora Ind & Comercial Ltda, Ribeirao Preto, SP - Brazil
[4] Univ Sao Paulo, Ribeirao Preto Med Sch, Dept Pathol, Ribeirao Preto, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Ethnopharmacology; v. 252, APR 24 2020.
Web of Science Citations: 1

Ethnopharmacological relevance: Propolis is a natural product produced by honeybees used as a medicine at least to 300 BC. In the last decades, several studies showed biological and pharmacological properties of propolis, witch scientifically explains the empirical use for centuries. The anti-inflammatory activity of propolis with the purpose to reduce Th2 inflammation has been evaluated in allergic asthma. However, it remains to be determined how propolis negatively regulates the immune response after allergen re-exposure. Aim of the study: We hypothesized that the anti-inflammatory activity of propolis is dependent on the induction of myeloid derived suppressor cells (MDSC) and regulatory T cells. Materials and methods: To assess this hypothesis, we used an ovalbumin-induced asthma model to evaluate the effect of EPP-AF(center dot) dry extract from Brazilian green propolis. Results: Propolis treatment decreased pulmonary inflammation and mucus production as well as eosinophils and IL-5 in the broncoalveolar lavage. Propolis enhanced also in vitro differentiation and in vivo frequency of lung MDSC and CD4(+)Foxp3(+) regulatory T cells. Conclusions: Together these results confirm the immunomodulatory potential of propolis during sensitization and challenge with allergen. In addition, the collecting findings show, for the first time, that propolis increases the frequency of MDSC and CD4(+)Foxp3(+) regulatory T cells in the lungs, and suggest that it could be use as target for development of new immunotherapy or adjuvant immunotherapy for asthma. (AU)

FAPESP's process: 13/08216-2 - CRID - Center for Research in Inflammatory Diseases
Grantee:Fernando de Queiroz Cunha
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 11/09702-2 - Role of dendritic cells in the differentiation of CD4+ cell populations in mice with different ability to generate cellular immune response against Mycobacterium tuberculosis
Grantee:Vânia Luiza Deperon Bonato
Support Opportunities: Regular Research Grants
FAPESP's process: 15/15963-4 - Efficacy and safety determination of active principle of natural origin and nanoparticles development for rheumatoid arthritis treatment
Grantee:Juliana Issa Hori
Support Opportunities: Research Grants - Innovative Research in Small Business - PIPE