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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

MicroRNA-126 upregulation, induced by training, plays a role in controlling microcirculation in dexamethasone treated rats

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Herrera, Naiara A. [1] ; Duchatsch, Francine [1] ; Tardelli, Lidieli P. [1] ; Dionisio, Thiago J. [2] ; Shinohara, Andre L. [2] ; Santos, Carlos F. [2] ; Amaral, Sandra Lia [1, 3]
Total Authors: 7
[1] PIPGCF UFSCar UNESP, Joint Grad Program Physiol Sci, Rodovia Washington Luiz, Km 235 Monjolinho 676, BR-1356590 Sao Carlos, SP - Brazil
[2] Univ Sao Paulo, Bauru Sch Dent, Dept Biol Sci, Alameda Octavio Pinheiro Brisolla 9-75, BR-17012901 Bauru, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Sch Sci, Dept Phys Educ, Av Eng Luiz Edmundo Carrijo Coube 14-01, BR-17033360 Bauru, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Molecular and Cellular Endocrinology; v. 505, APR 5 2020.
Web of Science Citations: 0

Microcirculation maintenance is associated with microRNAs. Nevertheless, the role of microRNAs induced by training in preventing dexamethasone (DEX)-induced microvascular rarefaction remains unknown. The study aim was to investigate if training-induced microRNAs are able to improve microcirculation proteins and prevent DEX-induced microvascular rarefaction. Rats underwent training for 8 weeks and then were treated with DEX (50 mu g/kg per day, s.c.) for 14 days. Arterial pressure was measured and tibialis anterior (TA) muscle was collected for analyses. DEX induced hypertension concomitantly with capillary density loss (CD, -23.9%) and decrease of VEGF (-43.0%), p-AKT/AKT (-39.6%) and Bcl-2 (-23.0%) and an increase in caspase-3-cleaved protein level (+34.0%) in TA muscle. Training upregulated microRNA-126 expression (+13.1%), prevented VEGF (+61.4%), p-AKT/AKT (+37.7%), Bcl-2 (+7.7%) decrease and caspase-3-cleaved (-23.1%) increase associated with CD (+54.7%) reduction and hypertension prevention. MiRNA-126 upregulation, induced by training, plays a role in controlling microcirculation, which may be a potential target against DEX-induced microvascular rarefaction. (AU)

Grantee:Naiara Araújo Herrera
Support Opportunities: Scholarships abroad - Research Internship - Doctorate
FAPESP's process: 17/14405-3 - Influence of aerobic physical training on cardiac remodeling of spontaneously hypertensive rats treated with dexamethasone
Grantee:Francine Duchatsch Ribeiro de Souza
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 16/12532-5 - Exercise training effects on SHR treated with dexamethasone: role of miRNAs
Grantee:Naiara Araújo Herrera
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/00509-1 - Role of physical training on autonomic balance, arterial stiffness and rarefaction in spontaneously hypertensive rats treated with dexamethasone: role of miRNA
Grantee:Sandra Lia do Amaral Cardoso
Support Opportunities: Regular Research Grants
FAPESP's process: 15/03965-2 - Role of the renin-angiotensin system in different oral inflammatory models: an experimental interdisciplinary and clinical approach
Grantee:Carlos Ferreira dos Santos
Support Opportunities: Research Projects - Thematic Grants