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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Biocompatible superparamagnetic nanoparticles with ibuprofen as potential drug carriers

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Author(s):
Campos, Isabelle [1] ; Espindola, Ariane [1] ; Chagas, Camila [2] ; Barbosa, Emerson [2] ; Castro, Carlos E. [3] ; Molina, Celso [1] ; Fonseca, Fernando L. A. [1, 2] ; Haddad, Paula S. [1]
Total Authors: 8
Affiliation:
[1] Fed Univ Sao Paulo UNIFESP, Dept Chem, Diadema, SP - Brazil
[2] Fac Med ABC FMABC, Santo Andre, SP - Brazil
[3] Fed Univ ABC UFABC, CCNH, Santo Andre, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SN APPLIED SCIENCES; v. 2, n. 3 MAR 2020.
Web of Science Citations: 0
Abstract

This article describes the synthesis, characterization, in vitro cytotoxic and genotoxicity evaluation of chitosan-iron oxide nanoparticles (Fe3O4-CS) as vehicles for ibuprofen (IBU) molecule. Magnetite (Fe3O4) nanoparticles were synthesized by co-precipitation of iron salts and coated with chitosan, leading to the formation of Fe3O4-CS hybrid nanoparticles, and then IBU was adsorbed on the surface of the modified nanoparticles.The physicochemical, morphological, and magnetic properties of the nanoparticles were determined by X-ray powder diffraction, Fourier transform infrared spectroscopy, scanning electron microscopy, transmission electron microscopy and SQUID magnetic measurements. The nanoparticles have shown stability in aqueous medium presenting an average hydrodynamic size of 36 +/- 9 nm for Fe3O4-CS, and 132 +/- 1 nm for Fe3O4-CS-IBU. The cytotoxicity of nanoparticles using the cell viability of the blood mononuclear cell fraction and the analysis of gene expression of the repair genes hMSH2, hMSH6 and NF-kB were performed to evaluate their applicability as drug carriers. The results showed that Fe3O4-CS nanoparticles are suitable candidates as magnetic vehicles for ibuprofen in biomedical applications. {[}GRAPHICS] . (AU)

FAPESP's process: 18/12219-0 - Evaluation of toxicity and antineoplastic action in BALB/c mice inoculated with Ehrlich's Tumor treated with superparamagnetic nanoparticles
Grantee:Camila dos Santos Chagas
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 17/15061-6 - Preparation, Characterization and Biological Essay of Nanostructured Materials Based on Superparamagnetic Metallic and Bimetallic Nanoparticles
Grantee:Paula Silvia Haddad Ferreira
Support Opportunities: Regular Research Grants
FAPESP's process: 16/22478-8 - Synthesis, characterization and biomedical assays of iron oxide nanoparticles
Grantee:Isabelle de Souza Campos
Support Opportunities: Scholarships in Brazil - Scientific Initiation