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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Anxiogenesis induced by social defeat in male mice: Role of nitric oxide, NMDA, and CRF1 receptors in the medial prefrontal cortex and BNST

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Faria, M. P. [1, 2] ; Laverde, C. F. [1, 2] ; Nunes-de-Souza, R. L. [1, 2]
Total Authors: 3
[1] UNESP, Joint Grad Program Physiol Sci PIPGCF UFSCar, BR-14800903 Araraquara, SP - Brazil
[2] Sao Paulo State Univ, Sch Pharmaceut Sci, Lab Pharmacol, UNESP, Araraquara, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Neuropharmacology; v. 166, APR 2020.
Web of Science Citations: 0

Nitric oxide (NO) release in the right medial prefrontal cortex (RmPFC) produces anxiogenesis. In the bed nucleus of the stria terminalis (BNST), a region that receives neuronal projections from the mPFC, NO provokes anxiety, an effect that is blocked by local injections of corticotrophin-releasing factor type 1 receptor (CRF1) or n-methyl-D-aspartate receptor (NMDAr) antagonist. Anxiety is also enhanced by social defeat stress, and chronic stress impairs and facilitates, respectively, PFC and BNST roles in modulating behavioral responses to aversive situations. This study investigated whether the (i) chronic social defeat stress (CSDS) increases NO signaling in the mPFC; and/or (ii) anxiogenic effects provoked by the intra-RmPFC injection of NOC-9 (an NO donor) or by CSDS are prevented by intra-BNST injections of AP-7 (0.05 nmol) or CP 376395 (3.0 nmol), respectively, NMDAr and CRF1 antagonists, in male Swiss-Webster mice exposed to the elevated plus-maze (EPM). Results showed that (a) CSDS increased anxiety (i.e., reduced open-arm exploration) and repeatedly activated nNOS-containing neurons, as measured by Delta FosB (a stable nonspecific marker of neural activity) + nNOS double-labeling, in the right (but not left) mPFC, (b) NOC-9 in the RmPFC also increased anxiety, and (c) both CSDS and NOC-9 effects were reversed by injections of AP-7 or CP 376395 into the BNST. These results suggest that NMDA and CRF1 receptors located in BNST play an important role in the modulation of anxiety provoked by NO in the RmPFC, as well as by chronic social defeat in mice. (AU)

FAPESP's process: 17/25409-0 - Neurobiological substrates of the medial prefrontal cortex functional lateralization on defensive reactions induced by social defeat stress in mice
Grantee:Ricardo Luiz Nunes de Souza
Support type: Regular Research Grants