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(Reference retrieved automatically from SciELO through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinical and subclinical maternal hypothyroidism and their effects on neurodevelopment, behavior and cognition

Full text
Author(s):
Alice Batistuzzo [1] ; Miriam Oliveira Ribeiro [2]
Total Authors: 2
Affiliation:
[1] Universidade Presbiteriana Mackenzie. Centro de Ciências Biológicas e da Saúde. Departamento de Pós-Graduação em Distúrbios do Desenvolvimento - Brasil
[2] Universidade Presbiteriana Mackenzie. Centro de Ciências Biológicas e da Saúde. Departamento de Pós-Graduação em Distúrbios do Desenvolvimento - Brasil
Total Affiliations: 2
Document type: Journal article
Source: ARCHIVES OF ENDOCRINOLOGY METABOLISM; v. 64, n. 1, p. 89-95, 2020-03-13.
Abstract

ABSTRACT Clinical and subclinical hypothyroidism are the most common hormonal dysfunctions during pregnancy. Insufficient maternal thyroid hormones (THs) in the early stages of pregnancy can lead to severe impairments in the development of the central nervous system because THs are critical to central nervous system development. In the fetus and after birth, THs participate in neurogenic processes, cell differentiation, neuronal activation, axonal growth, dendritic arborization, synaptogenesis and myelination. Although treatment is simple and effective, approximately 30% of pregnant women in Brazil with access to prenatal care have their first consultation after the first trimester of pregnancy, and any delay in diagnosis and resulting treatment delay may lead to cognitive impairment in children. This review summarizes the effects of clinical and subclinical hypothyroidism on fetal neurodevelopment, behavior and cognition in humans and rodents. Arch Endocrinol Metab. 2020;64(1):89-95 (AU)

FAPESP's process: 17/18277-0 - Thr92Ala-D2 polimorphism and behavior
Grantee:Miriam Oliveira Ribeiro
Support type: Regular Research Grants