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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Characterizing hand and wrist ultrasound pattern in primary Sjogren's syndrome: a case-control study

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Guedes, L. K. N. [1] ; Leon, E. P. [1] ; Bocate, T. S. [1] ; Bonfigliolli, K. R. [1] ; Lourenco, V, S. ; Bonfa, E. [1] ; Pasoto, S. G. [1]
Total Authors: 7
[1] Univ Sao Paulo, Hosp Clin, Rheumatol Div, Fac Med, Av Dr Arnaldo 455, 3 Andar, Sala 3190, BR-01246903 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: CLINICAL RHEUMATOLOGY; v. 39, n. 6 FEB 2020.
Web of Science Citations: 0

Introduction/objectives To evaluate the clinical relevance of high-resolution hand and wrist ultrasound (US) findings and their possible associations with anti-citrullinated peptide antibodies in primary Sjogren's syndrome (pSS). Methods Ninety-seven consecutive pSS patients (American-European Consensus Group, 2002) without meeting the American College of Rheumatology (ACR) criteria (1987) for rheumatoid arthritis (RA); 20 RA patients (ACR/European League Against Rheumatism (EULAR) criteria, 2010); and 80 healthy individuals with comparable age, gender, and ethnicity were enrolled in a case-control study. Disease activity was assessed by EULAR Sjogren's Syndrome Disease Activity Index (ESSDAI). US was performed by one expert blinded to anti-CCP, anti-MCV, and IgM rheumatoid factor tested by ELISA. Results Frequencies of grade 3 synovitis (9.3 vs. 0%, p = 0.004), tenosynovitis (36.1 vs. 3.8%, p < 0.001), and erosions (27.8 vs. 7.5%, p = 0.001) on US were higher in pSS patients than in healthy controls. ESSDAI presented a moderate correlation with the synovitis number (p = 0.001) and tenosynovitis (p < 0.001). Most pSS patients with erosions on US (81.5%) had negative anti-CCP. Nevertheless, anti-CCP >= 3x cut-off value was associated with the presence of erosions in pSS (p = 0.026). Erosions in pSS were mainly small size contrasting with moderate/large size in RA (p < 0.001), and positive power Doppler synovitis predominated in RA (p < 0.001). Conclusions US identified significant frequencies of grade 3 synovitis, tenosynovitis, and erosions in pSS. Synovitis and tenosynovitis numbers were correlated with ESSDAI. Association between erosions on US and anti-CCP (high titers) in pSS possibly identifies a subgroup with severe arthritis. These findings suggest that US is a useful method for assessing joint involvement in pSS. (AU)

FAPESP's process: 10/10013-4 - Serum autoantibodies in primary Sjögren's syndrome: study of clinical associations and possible correlations with antibodies to viral antigens (EBV and HTLV-1)
Grantee:Sandra Gofinet Pasoto
Support type: Regular Research Grants