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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Nanostructured titanium alloy surfaces for enhanced osteoblast response: A combination of morphology and chemistry

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Rangel, Andre L. R. [1] ; Falentin-Daudre, Celine [2] ; Alves da Silva Pimentel, Bruna Natalia [3] ; Vergani, Carlos Eduardo [3] ; Migonney, Veronique [2] ; Alves Claro, Ana P. R. [1]
Total Authors: 6
[1] UNESP Sao Paulo State Univ, Sch Engn Mat & Technol Dept, Guaratingueta Campus, Sao Paulo, SP - Brazil
[2] Univ Paris 13, CSPBAT LBPS, Paris - France
[3] UNESP Sao Paulo State Univ, Dent Sch, Dent & Prosthodont Dept, Araraquara Campus, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: SURFACE & COATINGS TECHNOLOGY; v. 383, FEB 15 2020.
Web of Science Citations: 0

This study is part of a new trend in the metallic biomaterials field that searches to use the titanium beta alloys with recognized bulk and surface properties for better biological response. Ti15Mo alloy (wt%) had it surface modified by TiO2 nanotubes growth using the anodic oxidation method and grafted with poly(sodium styrene sulfonate) (PNaSS). The motivation behind the combination of these techniques was to promote a surface, which enables better osteointegration associated with antimicrobial behavior. Surfaces were characterized and subjected to cell culture assays and bacterial colonization to evaluate their in vitro response. The results showed that the surfaces were completely covered with TiO2 nanotubes, which was successfully grafted with PNaSS. Compared with untreated Ti 15Mo surfaces, PNaSS grafted nanotubes surfaces showed better osteoblast cell response in terms of cell attachment and mineralization and weaker bacterial adhesion and colonization. The results suggest that the final product of the combine treatment - nanotube plus PNaSS grafting - represents a promising option to improve commercial metallic implants. (AU)

FAPESP's process: 15/25124-0 - Effect of antimicrobial and cytotoxic properties of ±-Ag2WO4 and ²-Ag2MoO4 as titanium coating materials surfaces
Grantee:Carlos Eduardo Vergani
Support type: Regular Research Grants
FAPESP's process: 15/13834-2 - Evaluation of the antifungal activity and cytotoxicity of alpha silver vanadate (a-AgVO3) microcrystals sinthesized in different temperatures
Grantee:Bruna Natalia Alves da Silva Pimentel
Support type: Scholarships in Brazil - Master
FAPESP's process: 13/00317-4 - Surface modification of the Ti-15Mo alloy for drug delivery
Grantee:André Luiz Reis Rangel
Support type: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 15/26273-9 - Surface modification of Ti-15Mo alloys to drugs release
Grantee:André Luiz Reis Rangel
Support type: Scholarships abroad - Research Internship - Doctorate (Direct)