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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of COLIA1-1997 G/T polymorphism as a related factor to genital prolapse

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Palos, Claudia Cristina [1] ; Timm, Beatriz Ferreira [2] ; Paulo, Denise de Souza [1] ; Fernandes, Cesar Eduardo [1] ; de Souto, Ricardo Peres [2] ; Oliveira, Emerson [1]
Total Authors: 6
[1] ABC Med Sch, Discipline Gynecol, Dept Urogynecol & Vaginal Surg, Santo Andre, SP - Brazil
[2] ABC Med Sch, Dept Morphol & Physiol, Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: INTERNATIONAL UROGYNECOLOGY JOURNAL; v. 31, n. 1, p. 133-137, JAN 2020.
Web of Science Citations: 0

Introduction and hypothesis Pelvic organ prolapse has a multifactorial etiology. There is increasing evidence that genetic factors greatly impact its development. This study aimed to evaluate the possible relation of the collagenous polymorphism -1997 G/T with genital prolapse in Brazilian women. Methods A cohort study of 180 women with stage 0 or I (group A) pelvic organ prolapse disorder and 112 women with stage III or IV (group B) was conducted. Blood DNA was isolated, and the -1997 G/T polymorphism was identified by amplifying a region of the COLIA1 gene starting prior to the protein's coding sequence. Results No significant difference in the prevalence of genotypes TG and TT was found between groups (p = 0.67); differences were not found even when patients were grouped by the presence of 0 or >= 1 polymorphic alleles (p = 0.46). Age and home birth were found to be independent risk factors for prolapse. Conclusions Our study could not find any association between the -1997G/T polymorphism and genital prolapse in Brazilian women. (AU)

FAPESP's process: 14/01107-6 - Analysis of polymorphisms of genes responsible for the biosynthesis and metabolism of collagen as risk factors for development of genital prolapse
Grantee:Emerson de Oliveira
Support Opportunities: Regular Research Grants