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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Polymorphism rs1800255 from COL3A1 gene and the risk for pelvic organ prolapse

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Teixeira, Fernando Henrique [1] ; Fernandes, Cesar Eduardo [1] ; Souto, Ricardo Peres [1] ; de Oliveira, Emerson [1]
Total Authors: 4
[1] Fac Med ABC, Av Lauro Gomes 2000, BR-09060870 Santo Andre, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: INTERNATIONAL UROGYNECOLOGY JOURNAL; v. 31, n. 1, p. 73-78, JAN 2020.
Web of Science Citations: 0

Introduction and hypothesis Genetic variations of type III collagen may compromise the supportive structures of the female pelvic floor and consequently favor pelvic organ prolapse. The single nucleotide polymorphism G/A rs1800255 located in the coding region for type III collagen (COL3A1) was evaluated as a risk factor for pelvic organ prolapse. Methods A single-center prospective cohort study including women with clinical diagnosis of stage III and IV prolapse (POP group) and prolapse stage 0 or I (control group). Sociodemographic, clinical data and obstetric history were retrieved by physician interview. DNA including the rs1800255 polymorphism was amplified by polymerase chain reaction from blood genomic cells and digested with AluI restriction enzyme for distinction of G and A variants. Qualitative variables were compared using the chi-square and Fisher's exact tests and unpaired t-test for quantitative variables. After stratification of the groups, risk factors for POP were estimated using odds ratios (ORs) from the binary logistic regression model. Results A total of 292 women were included, 112 in the POP group and 180 in the control group. There was no significant difference between groups regarding rs1800255. Age and home birth were the only significant risk factors for pelvic organ prolapse. Conclusion Polymorphism rs1800255 from COL3A1 gene was not a risk factor for pelvic organ prolapse. (AU)

FAPESP's process: 14/01107-6 - Analysis of polymorphisms of genes responsible for the biosynthesis and metabolism of collagen as risk factors for development of genital prolapse
Grantee:Emerson de Oliveira
Support Opportunities: Regular Research Grants