Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Levels of Polonium-210 in brain and pulmonary tissues: Preliminary study in autopsies conducted in the city of Sao Paulo, Brazil

Full text
dos Santos, Nathalia Villa [1] ; Zilli Vieira, Carolina Leticia [2] ; Nascimento Saldiva, Paulo Hilario [1] ; Mazzilli, Barbara Paci [3] ; Saiki, Mitiko [3] ; Saueia, Catia Heloisa [3] ; Saldiva De Andre, Carmen Diva [4] ; Justo, Lisie Tocci [1] ; Nisti, Marcelo Bessa [3] ; Koutrakis, Petros [2]
Total Authors: 10
[1] Univ Sao Paulo, Dept Pathol, Lab Expt Air Pollut, Sch Med, Sao Paulo, SP - Brazil
[2] Harvard TH Chan Sch Publ Hlth, Dept Environm Hlth, Boston, MA 02115 - USA
[3] IPEN CNEN, Nucl & Energy Res Inst, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Inst Math & Stat, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 10, n. 1 JAN 13 2020.
Web of Science Citations: 0

The accumulation of detectable amounts of radon progeny in human tissues may be a risk factor for development and progression of chronic diseases. In this preliminary study, we analyzed the levels of alpha-emitting radon progeny Polonium-210 (Po-210) in the olfactory epithelium, olfactory bulb, frontal lobe, and lung tissues in cadavers from the city of Sao Paulo, SP, Brazil. We also assessed the association between Po-210 levels and exposure parameters for urban air pollution using linear regression models adjusted for age, sex, smoke, time living in Sao Paulo, daily commuting, socioeconomic index, and anthracosis (traffic-related black carbon accumulation in the pleural region and in lymph). Our findings show that the concentration of Po-210 was associated with anthracosis in lungs of non-smokers (coefficient=6.0; standard error=2.9; p=0.04). Individuals with lower socioeconomic status also had significantly higher Po-210 levels in lungs (coefficient=-1.19; standard error=0.58; p=0.042). The olfactory bulb had higher Po-210 levels than either olfactory epithelium (p=0.071), frontal lobe (p<0.001), or lungs (p=0.037). Our findings of the deposition of Po-210 in autopsy tissues suggest that airborne radionuclides may contribute to the development of chronic diseases, including neurodegenerative diseases. (AU)

FAPESP's process: 13/21728-2 - The use of modern autopsy techniques to investigate human diseases (MODAU)
Grantee:Paulo Hilário Nascimento Saldiva
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/03461-7 - Comparison of minimally invasive autopsy and conventional autopsy for post-mortem malignant neoplasm diagnosis
Grantee:Lisie Tocci Justo Luvizutto
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/22793-0 - Alzheimer's Disease in the olfactory epithelium: correlation with the environment
Grantee:Nathalia Villa dos Santos
Support Opportunities: Scholarships in Brazil - Post-Doctoral
FAPESP's process: 16/23129-7 - Impact of long-term exposure to air pollution on myocardium ageing
Grantee:Ana Paula Cremasco Takano
Support Opportunities: Scholarships in Brazil - Post-Doctoral