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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Swimming Physical Training Prevented the Onset of Acute Muscle Pain by a Mechanism Dependent of PPAR gamma Receptors and CINC-1

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de Azambuja, Graciana [1] ; Gomes, Beatriz Botasso [1] ; Dalcheco Messias, Leonardo Henrique [2] ; Aquino, Bruna de Melo [1] ; Jorge, Carolina Ocanha [1] ; Manchado-Gobatto, Fulvia de Barros [2] ; Goncalves de Oliveira-Fusaro, Maria Claudia [1]
Total Authors: 7
[1] Univ Estadual Campinas, Sch Appl Sci, Lab Pain & Inflammat Res, Pedro Zaccaria St 1300, BR-13484350 Limeira, SP - Brazil
[2] Univ Estadual Campinas, Sch Appl Sci, Lab Appl Sport Physiol, Limeira, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Neuroscience; v. 427, p. 64-74, FEB 10 2020.
Web of Science Citations: 0

Regular physical exercise has been described as a good strategy for prevention or reduction of musculoskeletal pain. The Peroxisome Proliferator-Activated Receptor Gamma (PPAR gamma) has been investigated as a promising target for the control of inflammatory pain. Therefore, the aim of this study was to evaluate whether activation of PPAR gamma receptors is involved in the reduction of acute muscle pain by chronic exercise and, in this case, whether this process is modulated by inflammatory cytokines. To this end, Wistar rats were submitted to swimming physical training for a period of 10 weeks, 5 days per week, 40 min/day, in an intensity of 4% of the body mass. Muscle hyperalgesia was measured by Randall Selitto test and pro-inflammatory cytokines were quantified by ELISA. The results showed that swimming physical training prevented the onset of acute mechanical muscle hyperalgesia and the increase in muscle levels of Cytokine-induced neutrophil chemoattractant 1 (CINC-1) induced by carrageenan into gastrocnemius muscle. In addition, local pre-treatment with the selective PPAR gamma receptors antagonist GW9662 reversed the mechanical muscle hypoalgesia and the modulation of CINC-1 levels induced by swimming physical training. These data suggest that swimming physical training prevented the onset of acute mechanical muscle hyperalgesia by a mechanism dependent of PPAR gamma receptors, which seems to contribute to this process by modulation of the pro-inflammatory cytokine CINC-1, and highlight the potential of PPAR gamma receptors as a target to control musculoskeletal pain and to potentiate the reduction of musculoskeletal pain induced by exercise. (C) 2019 IBRO. Published by Elsevier Ltd. All rights reserved. (AU)

FAPESP's process: 15/20738-0 - Exercise Induces Hypoalgesia: Effect of chronic and individualized exercise and evaluation of the involvement of PPAR-³ receptors in this process
Grantee:Graciana de Azambuja
Support Opportunities: Scholarships in Brazil - Master