| Full text | |
| Author(s): |
Rossoni, Rodnei Dennis
[1]
;
de Barros, Patricia Pimentel
[1]
;
das Chagas Lopes, Lucas Alexandre
[1]
;
Ribeiro, Felipe Camargo
[1]
;
Nakatsuka, Toshiyuki
[2]
;
Kasaba, Hideto
[2]
;
Junqueira, Juliana Campos
[1]
Total Authors: 7
|
| Affiliation: | [1] UNESP Univ Estadual Paulista, Inst Sci & Technol, Dept Biosci & Oral Diag, Sao Jose Dos Campos - Brazil
[2] SHOFU Inc, Dept Res, Kyoto - Japan
Total Affiliations: 2
|
| Document type: | Journal article |
| Source: | BIOFOULING; NOV 2019. |
| Web of Science Citations: | 1 |
| Abstract | |
Surface pre-reacted glass-ionomer (S-PRG) is a bioactive filler produced by PRG technology, which is applied to various dental materials. The inhibitory effects of S-PRG eluate against Candida, the most common fungal oral pathogen, were investigated. Minimum inhibitory concentrations (MIC) and anti-biofilm activities were tested against Candida albicans, Candida glabrata, Candida krusei, and Candida tropicalis. For the in vivo study, Galleria mellonella was used as a model to evaluate the effects of S-PRG on toxicity, hemocyte counts and candidiasis. The MIC of S-PRG ranged from 5 to 40% (v/v). S-PRG eluate exhibited anti-biofilm activity for all the Candida species tested. Furthermore, injection of S-PRG eluate into G. mellonella was not toxic to the larvae and protected G. mellonella against experimental candidiasis. In addition, S-PRG eluate inhibited biofilm formation by C. albicans, C. glabrata, C. krusei, and C. tropicalis and exerted protective effects on G. mellonella against experimental candidiasis in vivo. (AU) | |
| FAPESP's process: | 19/05664-0 - Exploring the caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin c (ARTC) as new strategies to eliminate persisters cells of Candida albicans. |
| Grantee: | Patrícia Pimentel de Barros |
| Support type: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 17/19219-3 - Identification of bioactive substances produced by Lactobacillus paracasei 28.4 for the control of oral candidiasis |
| Grantee: | Rodnei Dennis Rossoni |
| Support type: | Scholarships in Brazil - Post-Doctorate |
| FAPESP's process: | 18/21239-5 - Galleria mellonella in antimicrobial drug discovery: bioactive substances extracted from probiotic against Candida albicans persisters |
| Grantee: | Rodnei Dennis Rossoni |
| Support type: | Scholarships abroad - Research Internship - Post-doctor |
| FAPESP's process: | 17/02652-6 - Evaluation of the immunomodulatory and antifungal effects of caffeic acid (CA), caffeic acid phenethyl ester (CAPE) and artepillin C (ARC) on C. albicans and development of candidiasis in in vivo model hosts |
| Grantee: | Patrícia Pimentel de Barros |
| Support type: | Scholarships in Brazil - Post-Doctorate |