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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Lentinus edodes Exposure before and after Fetus Implantation: Materno-Fetal Development in Rats with Gestational Diabetes Mellitus

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Laurino, Leticia F. [1] ; Viroel, Fabia J. M. [1] ; Caetano, Erika [1] ; Spim, Sara [1] ; Pickler, Thaisa B. [1] ; Rosa-Castro, Raquel M. [1] ; Vasconcelos, Edilma Albuquerque [1] ; Jozala, Angela F. [1] ; Hataka, Alessandre [2] ; Grotto, Denise [1] ; Gerenutti, Marli [1]
Total Authors: 11
[1] Univ Sorocaba, BR-18023000 Sorocaba, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Vet Med & Anim Sci, Dept Vet Clin Sci, BR-18610307 Botucatu, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NUTRIENTS; v. 11, n. 11 NOV 2019.
Web of Science Citations: 0

Background: The presence of beta-glucans and phenolic compounds in Lentinus edodes suggests this mushroom can be used as a nutritional supplement. Two gestational conditions (before and after fetus implantation) were evaluated, and Lentinus edodes exposure was performed in diabetes mellitus rat model induced by streptozotocin in pre-clinical tests. Methods: On the 20th day of pregnancy, cesarean sections were performed. Blood was collected for biochemical, hematologic parameters and oxidative stress biomarkers. Placenta and amniotic fluid were collected, and fetuses were analyzed through morphological evaluation. Results: The mushroom did not reduce the severe hyperglycemia of the mother-concept but promoted an increase in maternal insulin levels; reduced the levels of alanine aminotransferase, and aspartate aminotransferase, triglyceride and total cholesterol; protected the animals from post-implantation losses. Liver damage induced by streptozotocin was reversed in experimental groups. Conclusions: Lentinus edodes mushroom has antioxidant properties that can minimize the damage caused by gestational diabetes mellitus. (AU)

FAPESP's process: 15/24566-9 - Pre-clinical studies with Agaricus blazei, Lentinula edodes and Ganoderma lucidum, aiming to reduce the maternal and fetal damage caused by gestational diabetes.
Grantee:Marli Gerenutti
Support Opportunities: Regular Research Grants
FAPESP's process: 13/05765-5 - Assessment of biochemical and antioxidant parameters in rats exposed to Lentinula edodes (shiitake) and its possible use in metabolic disturbances
Grantee:Denise Grotto
Support Opportunities: Regular Research Grants