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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Distinct effects of cocaine and cocaine plus cannabis on neurocognitive functioning and abstinence: A six-month follow-up study

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de Oliveira Junior, Hercilio Pereira [1, 2] ; di Goncalves, Priscila [1, 2, 3] ; Ometto, Mariella [2] ; dos Santos, Bernardo [4] ; Malbergier, Andre [1] ; Amaral, Ricardo [1] ; Nicastri, Sergio [1, 2] ; de Andrade, Arthur Guerra [1] ; Cunha, Paulo Jannuzzi [1, 2]
Total Authors: 9
[1] Univ Sao Paulo, Fac Med, Grp Interdisciplinar Estudos Alcool & Drogas GREA, Dept & Inst Psiquiatria, Hosp Clin HCFMUSP, 785 Rua Dr Ovidio Pires de Campos, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Fac Med, Lab Psychiat Neuroimaging LIM 21, Dept & Inst Psiquiatria, Hosp Clin HCFMUSP, 785 Rua Dr Ovidio Pires de Campos, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Fac Med, Hosp Clin HCFMUSP, Serv Psicol & Neuropsicol, Inst Psiquiatria, 785 Rua Dr Ovidio Pires de Campos, Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Escola Enfermagem, 419 Ave Dr Eneas Carvalho Aguiar Cerqueira Cesar, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: DRUG AND ALCOHOL DEPENDENCE; v. 205, DEC 1 2019.
Web of Science Citations: 0

Background and Aims: Cannabis use is frequent among individuals with cocaine use disorder. Despite recent non-controlled studies advocating a therapeutic role of smoked cannabis, there is a paucity of evidence-based data on potential therapeutic and cognitive side-effects of this association. Methods: We examined 63 cocaine-addicted subjects who used cannabis more than 50 times in lifetime (COC + CAN), 24 cocaine-addicted patients who use cannabis less than 50 times (COC), and 36 controls (CON). Participants were evaluated with an extensive battery of neurocognitive tests after two weeks of supervised detoxification in an inpatient treatment program. Patients were followed up in one, three, and six months after discharge. Results: Both groups of patients performed worse than CON on working memory, processing speed, inhibitory control, mental flexibility, and decision making. COC + CAN performed worse than COC on speed processing, inhibitory control and sustained attention, while COC performed worse than COC + CAN on mental flexibility. Concomitant cannabis use did not decrease relapses to cocaine use after one, three and six months. Among COC + CAN, earlier cocaine and cannabis use, and impaired executive functioning were predictive of relapse on cocaine after six months. Conclusion: Our results did not support the recommendation of smoked cannabis as a safe therapeutic approach for cocaine-addicted patients due to significant negative cognitive side-effects and absence of efficacy. Further studies investigating frontal brain morphology, neuromaturation, and prescription of the non-psychoactive constituent of cannabis sativa cannabidiol among cocaine-addicted patients who use cannabis are warranted. (AU)

FAPESP's process: 11/19179-5 - Stimulus-response compatibility and emotional valence: an investigation of the neurological bases involved in the processing of spatial and emotional information
Grantee:Geraldo Busatto Filho
Support Opportunities: Regular Research Grants
FAPESP's process: 10/01272-6 - Research about the impact of neuropsychological rehabilitation on cocaine/crack dependents
Grantee:Priscila Dib Goncalves
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 10/15604-0 - White matter integrity of the corpus callosum and neuropsychological performance in maltreated children and adolescents: a brain morphometric and diffusion tensor imaging study
Grantee:Paulo Jannuzzi Cunha
Support Opportunities: Scholarships in Brazil - Post-Doctorate