de Souza, Ana Luiza R.
Barboza Ferreira, Leonardo Miziara
Kurokawa, Suzy S. S.
Kiill, Charlene P.
Ferreira, Natalia N.
Pyrrho, Alexandre dos Santos
Sarmento, Victor H. V.
Silva, Amelia M.
Gremiao, Maria Palmira D.
Ribeiro, Clovis A.
Total Authors: 11
 Sao Paulo State Univ UNESP, Inst Chem, R Prof Francisco Degni 55, BR-14800060 Araraquara, SP - Brazil
 Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Rodovia Araraquara Jau Km 1, BR-14801902 Araraquara, SP - Brazil
 Fed Univ Rio de Janeiro UFRJ, Dept Clin & Toxicol Anal, Fac Pharm, Av Carlos Chagas Filho 373, BR-21941902 Rio De Janeiro, RJ - Brazil
 Fed Univ Sergipe UFS, Dept Chem, Campus Prof Alberto de Carvalho, BR-49500000 Itabaiana, SE - Brazil
 Univ Tras Os Montes & Alto Douro UTAD, Dept Biol & Environm, Quinta Prados 1013, P-5001801 Vila Real - Portugal
 Univ Tras Os Montes & Alto Douro UTAD, Ctr Res & Technol Agroenvironm & Biol Sci CITAB, Quinta Prados 1013, P-5001801 Vila Real - Portugal
Total Affiliations: 6
COLLOIDS AND SURFACES B-BIOINTERFACES;
DEC 1 2019.
Web of Science Citations:
Hexagonal liquid crystals and supramolecular polymers from meglumine-based supra-amphiphiles were developed as drug delivery systems to be applied on the skin. The influence of fatty acid unsaturation on the structure and mechanical properties was evaluated. Moreover, we have investigated the system biocompatibility and how the type of water could influence its bioadhesive properties. Meglumine-oleic acid (MEG-OA) was arranged as hexagonal liquid crystals at 30-70 wt% water content, probably due to its curvature and increased water solubility. Meglumine-stearic acid (MEG-SA) at 10-80 wt% water content self-assembled as a lamellar polymeric network, which can be explained by the low mobility of MEG-SA in water due to hydrophobic interactions between fatty acid chains and H-bonds between meglumine and water molecules. Both systems have shown suitable mechanical parameters and biocompatibility, making them potential candidates to encapsulate therapeutic molecules for skin delivery. Moreover, a strong positive correlation between the amount of unfrozen bound water in meglumine-based systems and the bioadhesion properties was observed. This work shows that a better understanding of the physicochemical properties of a drug delivery system is extremely important for the correlation with the desired biological response and, thus, improve the product performance for biomedical applications. (AU)