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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Trypanosoma cruzi extracellular amastigotes selectively trigger the PI3K/Akt and Erk pathways during HeLa cell invasion

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Ferreira, Bianca Lima [1, 2] ; Ferreira, Eden Ramalho [1] ; Bonfim-Melo, Alexis [1] ; Mortara, Renato Arruda [1] ; Bahia, Diana [3]
Total Authors: 5
[1] Univ Fed Sao Paulo, Dept Microbiol Imunol & Parasitol, Escola Paulista Med, Rua Botucatu 862, BR-04023062 Sao Paulo, SP - Brazil
[2] Univ Fed Sao Paulo, Dept Med, Escola Paulista Med, Disciplina Infectol, Sao Paulo, SP - Brazil
[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Genet Ecol & Evolucao, Belo Horizonte, MG - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Microbes and Infection; v. 21, n. 10, p. 485-489, DEC 2019.
Web of Science Citations: 0

Cell invasion by Trypanosoma cruzi extracellular amastigotes involves different signaling pathways to induce phagocytosis-like mechanisms. Previous works indicated that PI3K/Akt, Src and Erk might be involved in EA invasion; however, participation of these molecules in this process remains elusive. Here, we observed that EA activated Akt, Erk but not Src. Interference of EA invasion with specific inhibitors corroborated this observation. Our results show that EA is capable of selectively triggering complex signaling pathways. Activation of PI3K/Akt and Erk, kinases related to actin cytoskeleton rearrangement and phagocytosis, reinforces the idea that T. cruzi EA subverts the phagocytic machinery during invasion. (C) 2019 The Authors. Published by Elsevier Masson SAS on behalf of Institut Pasteur. (AU)

FAPESP's process: 13/04249-3 - Study of protein kinases pathways involved in the invasion process of HeLa cells by Trypanosoma cruzi extracellular amastigotes (EAs)
Grantee:Bianca Rodrigues Lima Ferreira
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 11/51475-3 - Molecular and cellular biology of the parasitism by Trypanosoma cruzi
Grantee:José Franco da Silveira Filho
Support Opportunities: Research Projects - Thematic Grants