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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cardiovascular outcomes related to social defeat stress: New insights from resilient and susceptible rats

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Morais-Silva, Gessynger [1, 2] ; Costa-Ferreira, Willian [1, 2] ; Gomes-de-Souza, Lucas [1, 2] ; Pavan, Jacqueline C. [1] ; Crestani, Carlos C. [1, 2] ; Marin, Marcelo T. [1, 2]
Total Authors: 6
[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Pharmacol Lab, Araraquara, SP - Brazil
[2] UNESP, UFSCar, Joint Grad Program Physiol Sci PIPGCF, Sao Carlos, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NEUROBIOLOGY OF STRESS; v. 11, NOV 2019.
Web of Science Citations: 0

Stress exposure is an important risk factor for psychiatric and cardiovascular disorders. Two phenotypes related to coping with stress can be observed in rodents that experience chronic social defeat stress (SDS): susceptible, showing social avoidance and behavioral changes related to depression, and resilient, showing none of these alterations. Moreover, a strong correlation exists between depression and the development of or mortality due to cardiovascular diseases. Nevertheless, little is known about cardiovascular alterations related to SDS exposure in those phenotypes or their correlation with depressive-like behaviors. Using a chronic SDS protocol followed by the social interaction test, we identified Wistar rats as resilient or susceptible to SDS. Susceptible animals showed increased depressive-like behaviors with resting tachycardia and decreased heart rate variability (HRV) due to increased sympathetic tone in the heart and a less effective baroreflex. In contrast, resilient rats were protected from these alterations by increased vagal tone, resulting in greater HRV values. To our knowledge, our study is the first to indicate that harmful cardiovascular outcomes are related to depressive-like behaviors in susceptible rats and to suggest a mechanism by which resilient rats are protected from these changes. Also, our results suggest that enhanced HRV and vagal tone may be an important trait in resilient individuals. (AU)

FAPESP's process: 15/25308-3 - Dealing with the enemy: effects of the treatment with N-acetylcysteine in the susceptibility and resilience to the social defeat stress in rats
Grantee:Gessynger Morais Silva
Support type: Scholarships in Brazil - Doctorate