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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Melatonin Supplementation Decreases Hypertrophic Obesity and Inflammation Induced by High-Fat Diet in Mice

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Mendes de Farias, Talita da Silva [1] ; Cruz, Maysa Mariana [1] ; da Cunha de Sa, Roberta Cavalcante [1] ; Severi, Ilenia [2, 3] ; Perugini, Jessica [2, 3] ; Senzacqua, Martina [2, 3] ; Cerutti, Suzete Maria [1, 4] ; Giordano, Antonio [2, 3] ; Cinti, Saverio [2, 3] ; Cardoso Alonso-Vale, Maria Isabel [1, 4]
Total Authors: 10
[1] Univ Fed Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Postgrad Program Chem Biol, Diadema - Brazil
[2] Univ Ancona, Dept Expt & Clin Med, Politecn Marche, Ancona - Italy
[3] Univ Ancona, Ctr Obes, Politecn Marche, Ancona - Italy
[4] Univ Fed Sao Paulo UNIFESP, Inst Environm Sci Chem & Pharmaceut, Dept Biol Sci, Diadema - Brazil
Total Affiliations: 4
Document type: Journal article
Web of Science Citations: 0

Obesity results from critical periods of positive energy balance characterized by caloric intake greater than energy expenditure. This disbalance promotes adipose tissue dysfunction which is related to other comorbidities. Melatonin is a low-cost therapeutic agent and studies indicate that its use may improve obesity-related disorders. To evaluate if the melatonin is efficient in delaying or even blocking the damages caused by excessive ingestion of a high-fat diet (HFD) in mice, as well as improving the inflammatory profile triggered by obesity herein, male C57BL/6 mice of 8 weeks were induced to obesity by a HFD and treated for 10 weeks with melatonin. The results demonstrate that melatonin supplementation attenuated serum triglyceride levels and total and LDL cholesterol and prevented body mass gain through a decreased lipogenesis rate and increased lipolytic capacity in white adipocytes, with a concomitant increment in oxygen consumption and Pgc1a and Prdm16 expression. Altogether, these effects prevented adipocyte hypertrophy caused by HFD and reflected in decreased adiposity. Finally, melatonin supplementation reduced the crown-like-structure (CLS) formation, characteristic of the inflammatory process by macrophage infiltration into white adipose tissue of obese subjects, as well as decreased the gene expression of inflammation-related factors, such as leptin and MCP1. Thus, the melatonin can be considered a potential therapeutic agent to attenuate the metabolic and inflammatory disorders triggered by obesity. (AU)

FAPESP's process: 18/05485-6 - Effects of high fat diet and supplementation with omega-7 and omega-3 fatty acids on the browning process, proliferation and differentiation of mesenchymal cells contained in the stromal cell fraction from adipose tissue
Grantee:Maria Isabel Cardoso Alonso-Vale
Support type: Regular Research Grants
FAPESP's process: 17/08582-0 - Effects of treatment wih fish oil on metabolic and endocrine dysfunction of adipocytes isolated from animals with metabolic syndrome
Grantee:Roberta Dourado Cavalcante da Cunha de Sá
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/07638-9 - Melatonin supplementation effect on trans-differentation process from white adipose tissue to brown adipose tissue in obese mice
Grantee:Talita da Silva Mendes de Farias Carvalho
Support type: Scholarships abroad - Research Internship - Post-doctor
FAPESP's process: 15/03554-2 - The effects of melatonin supplementation on the development of obesity in mice
Grantee:Talita da Silva Mendes de Farias Carvalho
Support type: Scholarships in Brazil - Post-Doctorate