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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Clinicopathologic and microenvironmental analysis of primary cutaneous CD30-positive lymphoproliferative disorders: a 26 year experience from an academic medical center in Brazil

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Ferreira, Cristiane Rubia [1, 2, 3] ; Zhao, Shuchun [2] ; Sanches, Jose Antonio [4] ; Miyashiro, Denis [4] ; Cury-Martins, Jade [4] ; Azevedo, Raymundo Soares [1] ; Zerbini, Maria C. N. [1] ; Natkunam, Yasodha [2] ; Gratzinger, Dita [2]
Total Authors: 9
[1] Univ Sao Paulo, Dept Pathol, BR-01246 Sao Paulo, SP - Brazil
[2] Stanford Univ, Sch Med, Dept Pathol, Stanford, CA 94305 - USA
[3] Univ Hosp Sao Paulo Univ HU USP, Anat Pathol Serv, Rua Prof Lineu Prestes 2565, BR-05508000 Sao Paulo, SP - Brazil
[4] Univ Sao Paulo, Dept Dermatol, BR-01246 Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: DIAGNOSTIC PATHOLOGY; v. 14, n. 1 OCT 22 2019.
Web of Science Citations: 0

Background Primary cutaneous CD30+ lymphoproliferative disorders (pc-CD30-LPD) are a group of clonal T cell lymphoproliferative disorders that despite very similar tumor histology follow different and characteristic clinical courses, suggesting a homeostatic role of the tumor microenvironment. Little is known about tumor microenvironment and there is almost no literature about PD-L1 expression in pc-CD30-LPD. Methods This retrospective study presents a fully clinicopathologically characterized series of pc-CD30-LPDs from an academic medical center in Brazil, including 8 lymphomatoid papulomatosis (LyP), 9 primary cutaneous anaplastic large cell lymphoma (pcALCL) and 4 borderline lesions. All the cases were scored for FOXP3+ regulatory T-cells (Treg) and CD8+ cytotoxic tumor infiltrating lymphocytes (TIL) densities, as well as PD-L1 expression in tumor cells and tissue associated macrophages. The CD8+/FOXP3+ ratio was also evaluated. Results Among the 21 cases of pc-CD30-LPD, PD-L1 expression is frequent in both tumor cells and tissue associated macrophages in pc-CD30-LPD across categories, suggesting that the PD-L1 axis may be a common feature of pc-CD30-LPDs. While reactive T cell infiltrates vary widely from case to case, a common feature across pc-CD30-LPDs is higher density of CD8 than FOXP3 + T cells. The distribution of T cells within the lesions however differed between LyP and pcALCL: we found that LyP lesions tend to be permeated by CD8+ and FOXP3+ T cells, whereas pcALCL tend to be surrounded by a rim of CD8+ TIL and FOXP3+ Tregs with relatively lower density infiltrates in the center of the lesion. Conclusions LyP has a trend to have denser immune cells throughout the lesion, with higher FOXP3+ Treg and CD8+ TIL in the center than the edge comparing with pcALCL. PD-L1+ is frequent in tumor cells and tissue associated macrophages in pc-CD30-LPD. The differential distribution of CD8+ and FOXP3+ TILs in LyP as compared to pcALCL could provide a clue to the relapsing/remitting course of LyP as compared to the less frequent spontaneous regression of pcALCL. (AU)

FAPESP's process: 16/09180-0 - Characterization of genetic subgroups of anaplastic large cell lymphoma, ALK negative by fish technique in Brazilian cases
Grantee:Cristiane Rúbia Ferreira
Support type: Scholarships abroad - Research