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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Semi-synthesis of beta-keto-1,2,3-triazole derivatives from ethinylestradiol and evaluation of the cytotoxic activity

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Author(s):
Queiroz, Thayane M. [1] ; Orozco, Erika V. M. [1] ; Silva, Valdenizia R. [2] ; Santos, Luciano S. [2] ; Soares, Milena B. P. [2] ; Bezerra, Daniel P. [2] ; Porto, Andre L. M. [1]
Total Authors: 7
Affiliation:
[1] Univ Sao Paulo, Inst Quim Sao Carlos, Lab Quim Organ & Biocatalise, Av Joao Dagnone 1100, Ed Quim Ambiental, BR-13563120 Sao Carlos, SP - Brazil
[2] Fundacao Oswaldo Cruz, Ctr Pesquisa Goncalo Moniz, R Waldemar Falcao 121, BR-40296710 Salvador, BA - Brazil
Total Affiliations: 2
Document type: Journal article
Source: HELIYON; v. 5, n. 9 SEP 2019.
Web of Science Citations: 0
Abstract

In this study, we report our contribution to the application of the copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction for the synthesis of beta-keto-1,2,3-triazole derivatives 3a-f from ethinylestradiol and their application in the inhibition of two human cancer cells lines: human breast adenocarcinoma (MCF-7) and human hepatocellular carcinoma (HepG2). The beta-keto-1,2,3-triazole derivates 3a-f exhibited moderate cytotoxic activity for the HepG2 cells with IC50 values of 29.7 mu M (3a), 16.4 mu M (3b), 17.8 mu M (3c), 20.4 mu M (3d), 28.1 mu M (3e) and 28.2 mu M (3f). The semi-synthetic beta-keto-1,2,3-triazoles derivatives 3a-f were all characterized by FT-IR, NMR, HRMS and {[}alpha](D). (AU)

FAPESP's process: 14/18257-0 - New approaches in biocatalytic reactions
Grantee:Andre Luiz Meleiro Porto
Support Opportunities: Regular Research Grants
FAPESP's process: 16/20155-7 - Biocatalytic reactions of aminolysis and kinetic resolution by lipases and biodegradation of agrochemicals by microorganisms
Grantee:Andre Luiz Meleiro Porto
Support Opportunities: Regular Research Grants