Univ Fed Sao Paulo, Paulista Med Sch, Discipline Neurosci, Dept Neurol & Neurosurg, Sao Paulo, SP - Brazil
 Univ Sao Paulo, Lab Cellular Neurobiol, Dept Biophys & Physiol, Sao Paulo, SP - Brazil
 Univ Sao Paulo, Lab Nucl Med LIM 43, Dept Radiol & Oncol, Fac Med, Sao Paulo, SP - Brazil
 Univ Fed Sao Paulo, Movement Disorders Unit, Dept Neurol & Neurosurg, Paulista Med Sch, Sao Paulo, SP - Brazil
Total Affiliations: 4
SEP 14 2019.
Web of Science Citations:
Background Proechimys, an epilepsy-resistant rodent from Amazon Rainforest, is a promising alternative animal model for studying neurodegenerative disorders. Objectives: To evaluate behavioral and immunohistological changes in Proechimys after 6 - OHDA-induced model of PD. Methods: Following unilateral injections of 6 - OHDA into striatum, animals were assessed for exploratory behavior using the cylinder test. Brain sections were submitted to immunohistochemistry for tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), and ionized calcium-binding adaptor molecule 1 (lba-1). Results: We observed normal exploratory behavior during cylinder test in all animals. We could not detect changes in the expression of TH in both striatum and SNc, suggesting that Proechimys is resistant to dopaminergic neuronal degeneration. Glial activation was observed by an increase in Iba-1 expression in both striatum and SNc, and by an increase in GFAP expression in striatum. Conclusions: Proechimys represents a promising animal model for studying the mechanisms underlying the susceptibility of dopaminergic neurons to degeneration induced by 6 - OHDA. (AU)