Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Endogenous protection against the 6-OHDA model of Parkinson's disease in the Amazonian rodent Proechimys

Full text
Guimaraes Marques, Marcia Jonathas [1] ; Real, Caroline Cristiano [2, 3] ; Victorino, Daniella Balduino [1] ; Britto, Luiz Roberto [2] ; Cavalheiro, Esper Abrao [1] ; Scorza, Fulvio Alexandre [1] ; Ferraz, Henrique Ballalai [4] ; Scorza, Carla Alessandra [1]
Total Authors: 8
[1] Univ Fed Sao Paulo, Paulista Med Sch, Discipline Neurosci, Dept Neurol & Neurosurg, Sao Paulo, SP - Brazil
[2] Univ Sao Paulo, Lab Cellular Neurobiol, Dept Biophys & Physiol, Sao Paulo, SP - Brazil
[3] Univ Sao Paulo, Lab Nucl Med LIM 43, Dept Radiol & Oncol, Fac Med, Sao Paulo, SP - Brazil
[4] Univ Fed Sao Paulo, Movement Disorders Unit, Dept Neurol & Neurosurg, Paulista Med Sch, Sao Paulo, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Neuroscience Letters; v. 709, SEP 14 2019.
Web of Science Citations: 1

Background Proechimys, an epilepsy-resistant rodent from Amazon Rainforest, is a promising alternative animal model for studying neurodegenerative disorders. Objectives: To evaluate behavioral and immunohistological changes in Proechimys after 6 - OHDA-induced model of PD. Methods: Following unilateral injections of 6 - OHDA into striatum, animals were assessed for exploratory behavior using the cylinder test. Brain sections were submitted to immunohistochemistry for tyrosine hydroxylase (TH), glial fibrillary acidic protein (GFAP), and ionized calcium-binding adaptor molecule 1 (lba-1). Results: We observed normal exploratory behavior during cylinder test in all animals. We could not detect changes in the expression of TH in both striatum and SNc, suggesting that Proechimys is resistant to dopaminergic neuronal degeneration. Glial activation was observed by an increase in Iba-1 expression in both striatum and SNc, and by an increase in GFAP expression in striatum. Conclusions: Proechimys represents a promising animal model for studying the mechanisms underlying the susceptibility of dopaminergic neurons to degeneration induced by 6 - OHDA. (AU)

FAPESP's process: 16/06879-2 - Brain dynamics after stroke in a rodent from the Amazon rainforest
Grantee:Carla Alessandra Scorza Bahi
Support type: Regular Research Grants
FAPESP's process: 13/25049-2 - Correlation of cellular, molecular, behavioral and neurofunctional parameters in Parkinson’s Disease with physical exercise in an animal model and in human postmortem tissue
Grantee:Caroline Cristiano Real Gregório
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 16/17746-3 - Evaluation of the effects of benzodiazepines on the in vivo electrophysiological activity of the brain and in vitro neuronal viability in the Ts65Dn mouse model
Grantee:Daniella Balduino Victorino
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 12/50329-6 - Translational neuroscience of Alzheimer's disease: preclinical and clinical studies of b-amyloid peptide and other biomarkers
Grantee:Geraldo Busatto Filho
Support type: Research Projects - Thematic Grants