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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Distribution of local ancestry and evidence of adaptation in admixed populations

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Secolin, Rodrigo [1, 2, 3] ; Mas-Sandoval, Alex [4, 3] ; Arauna, Lara R. [3] ; Torres, Fabio R. [1, 2] ; de Araujo, Tania K. [1, 2] ; Santos, Marilza L. [1, 2] ; Rocha, Cristiane S. [1, 2] ; Carvalho, Benilton S. [1, 5] ; Cendes, Fernando [6, 1] ; Lopes-Cendes, Iscia [1, 2] ; Comas, David [3]
Total Authors: 11
[1] Brazilian Inst Neurosci & Neurotechnol BRAINN, Campinas, SP - Brazil
[2] Univ Campinas UNICAMP, Dept Med Genet & Genom Med, Campinas, SP - Brazil
[3] Univ Pompeu Fabra, Inst Evolutionary Biol CSIC UPF, Dept Ciencies Expt & Salut, Barcelona - Spain
[4] Univ Fed Rio Grande do Sul, Dept Genet, Porto Alegre, RS - Brazil
[5] Univ Campinas UNICAMP, Inst Math Stat & Sci Comp, Dept Stat, Campinas, SP - Brazil
[6] Univ Campinas UNICAMP, Dept Neurol, Campinas, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, SEP 25 2019.
Web of Science Citations: 0

Admixed American populations have different global proportions of European, Sub-Saharan African, and Native-American ancestry. However, individuals who display the same global ancestry could exhibit remarkable differences in the distribution of local ancestry blocks. We studied for the first time the distribution of local ancestry across the genome of 264 Brazilian admixed individuals, ascertained within the scope of the Brazilian Initiative on Precision Medicine. We found a decreased proportion of European ancestry together with an excess of Native-American ancestry on chromosome 8p23.1 and showed that this is due to haplotypes created by chromosomal inversion events. Furthermore, Brazilian non-inverted haplotypes were more similar to Native-American haplotypes than to European haplotypes, in contrast to what was found in other American admixed populations. We also identified signals of recent positive selection on chromosome 8p23.1, and one gene within this locus, PPP1R3B, is related to glycogenesis and has been associated with an increased risk of type 2 diabetes and obesity. These findings point to a selection event after admixture, which is still not entirely understood in recent admixture events. (AU)

FAPESP's process: 13/07559-3 - BRAINN - The Brazilian Institute of Neuroscience and Neurotechnology
Grantee:Fernando Cendes
Support Opportunities: Research Grants - Research, Innovation and Dissemination Centers - RIDC
FAPESP's process: 16/14423-9 - Studying the genetic structure of a population from a specific geographic region: a comparative study using common, rare and structural variants.
Grantee:Rodrigo Secolin
Support Opportunities: Scholarships abroad - Research Internship - Post-doctor