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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of the HIV GWG variant in the HIV infection progression in mono and HCV coinfected patients

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Hebeler-Barbosa, Flavia [1, 2] ; Massolini, Viviam Milanez [2] ; Watanabe, Thais [3] ; Silva, Giovanni Faria [1] ; Barbosa, Alexandre Naime [1] ; Simoes, Rafael Plana [3] ; Ferrasi, Adriana Camargo [1, 2] ; de Andrade Zanotto, Paolo Marinho [4] ; de Moura Campos Pardini, Maria Ines [1, 2] ; Tommasini Grotto, Rejane Maria [3, 2]
Total Authors: 10
[1] Sao Paulo State Univ, UNESP, Med Sch, Botucatu, SP - Brazil
[2] Blood Transfus Ctr, Mol Biol Lab, Botucatu, SP - Brazil
[3] Sao Paulo State Univ, UNESP, Sch Agr, Botucatu, SP - Brazil
[4] Univ Sao Paulo, Lab Mol Evolut & Bioinformat LEMB, Biomed Sci Inst, Sao Paulo - Brazil
Total Affiliations: 4
Document type: Journal article
Source: MEDICINE; v. 98, n. 29 JUL 2019.
Web of Science Citations: 0

The HIV subtype B is the most frequent in Brazil. The HIV subtype B' codes the amino acids glicine-tryptophan-glicine (GWG) instead of glicine-proline-glicine on the tip of gp120 V3 loop. This variant was associated to a slower HIV progression in mono-infected patients; however, there is no information in coinfected patients. This study evaluated the infection progression of HIV variant B' on the hepatitis C virus presence. RNA isolated from plasma of the 601 infected patients were used to human immunodeficiency virus (HIV) subtyping and to classify the virus according their syncytium-inducing ability. The HIV infection progression was evaluated by clinical and laboratorial data. The results showed a significant association between HIV B' variant and CD4 count and time of AIDS in HIV mono-infected patients. Notwithstanding the fact that we did not find a direct association between GWG variant and AIDS and in HIV coinfected patients no mitigating effect due to GWG presence was found. We did observe that the association between GWG variant and CD4 counts is lost in coinfected patients. This is first work showing influence of the HIV GWG variant in coinfected patients. Nevertheless, the presence of the GWG variant can indicate a better prognostic in the mono-infected patients. (AU)

FAPESP's process: 17/07711-0 - Detection of ZIKA Virus (ZIKV), after in vitro exposition, in the Peripheral Blood Mononuclear Cells and Platelets from non-infected individuals: Influence of the Genetic Polymorphisms
Grantee:Rejane Maria Tommasini Grotto
Support Opportunities: Regular Research Grants
FAPESP's process: 13/21214-9 - Assessment of genetic polymorphisms on progression to AIDS in patients mono-infected and co-infected with human immunodeficiency virus (HIV) and hepatitis C virus (HCV)
Grantee:Rejane Maria Tommasini Grotto
Support Opportunities: Regular Research Grants