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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effect of Photodynamic Therapy on Microorganisms Responsible for Dental Caries: A Systematic Review and Meta-Analysis

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Author(s):
de Oliveira, Analu Barros [1] ; Ferrisse, Tulio Morandin [1] ; Marques, Raquel Souza [1] ; de Annunzio, Sarah Raquel [2] ; Brighenti, Fernanda Lourencao [1] ; Fontana, Carla Raquel [2]
Total Authors: 6
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Dent, BR-14801903 Sao Paulo - Brazil
[2] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, BR-14800903 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Review article
Source: INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES; v. 20, n. 14 JUL 2 2019.
Web of Science Citations: 1
Abstract

The aim of this study was to perform a systematic review of the literature followed by a meta-analysis about the efficacy of photodynamic therapy (PDT) on the microorganisms responsible for dental caries. The research question and the keywords were constructed according to the PICO strategy. The article search was done in Embase, Lilacs, Scielo, Medline, Scopus, Cochrane Library, Web of Science, Science Direct, and Pubmed databases. Randomized clinical trials and in vitro studies were selected in the review. The study was conducted according the PRISMA guideline for systematic review. A total of 34 articles were included in the qualitative analysis and four articles were divided into two subgroups to perform the meta-analysis. Few studies have achieved an effective microbial reduction in microorganisms associated with the pathogenesis of dental caries. The results highlight that there is no consensus about the study protocols for PDT against cariogenic microorganisms, although the results showed the PDT could be a good alternative for the treatment of dental caries. (AU)

FAPESP's process: 18/23015-7 - Antimicrobial photodynamic therapy by continuous and switched mode irradiation against Enterococcus faecalis and Cutibacterium acnes
Grantee:Carla Raquel Fontana Mendonça
Support Opportunities: Regular Research Grants
FAPESP's process: 18/18440-0 - Bioprospection of natural products in photodynamic therapy against microorganisms of medial and dental importance
Grantee:Analú Barros de Oliveira
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 18/09088-1 - Assessment of photodynamic therapy against polymicrobial acne biofilms: a preclinical study
Grantee:Sarah Raquel de Annunzio
Support Opportunities: Scholarships in Brazil - Doctorate