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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

A Shift in the Activation of Serotonergic and Non-serotonergic Neurons in the Dorsal Raphe Lateral Wings Subnucleus Underlies the Panicolytic-Like Effect of Fluoxetine in Rats

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Author(s):
Vilela-Costa, Heloisa Helena [1] ; Spiacci Jr, Ailton ; Bissolli, Isabella Galante [2] ; Zangrossi Jr, Helio
Total Authors: 4
Affiliation:
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Spiacci Jr, Jr., Ailton, Univ Sao Paulo, Sch Med Ribeirao Preto, Dept Pharmacol, Av Bandeirantes 3900, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Molecular Neurobiology; v. 56, n. 9, p. 6487-6500, SEP 2019.
Web of Science Citations: 1
Abstract

A wealth of evidence indicates that the lateral wings subnucleus of the dorsal raphe nucleus (lwDR) is implicated in the processing of panic-associated stimuli. Escape expression in the elevated T-maze, considered a panic-related defensive behavior, markedly and selectively recruits non-serotonergic cells within this DR subregion and in the dorsal periaqueductal gray (dPAG), another key panic-associated area. However, whether anti-panic drugs may interfere with this pattern of neuronal activation is still unknown. In the present study, the effects of acute (10 mg/kg) or chronic fluoxetine (10 mg/kg/daily/21 days) treatment on the number of serotonergic and non-serotonergic cells induced by escape expression within the rat DR and PAG subnuclei were investigated by immunochemistry. The results showed that chronic, but not acute, treatment with fluoxetine impaired escape expression, indicating a panicolytic-like effect, and markedly decreased the number of non-serotonergic cells that were recruited in the lwDR and dPAG. The same treatment selectively increased the number of serotonergic neurons within the lwDR. Our immunochemistry analyses also revealed that the non-serotonergic cells recruited in the lwDR and dPAG by the escape expression were not nitrergic. Overall, our findings suggest that the anti-panic effect of chronic treatment with fluoxetine is mediated by stimulation of the lwDR-dPAG pathway that controls the expression of panic-associated escape behaviors. (AU)

FAPESP's process: 17/18437-7 - Investigation of the role of 5-HT1A receptors located in the lateral wings of the dorsal raphe nucleus on the panicolytic effect promoted by fluoxetine treatment
Grantee:Heloísa Helena Vilela Costa
Support type: Scholarships in Brazil - Post-Doctorate
FAPESP's process: 13/05903-9 - Effect of administration of fluoxetine and imipramine on serotonergic neurotransmission in different subregions of the dorsal raphe nucleus and dorsal periaqueductal gray of rats exposed to model elevated T maze
Grantee:Heloísa Helena Vilela Costa
Support type: Scholarships in Brazil - Doctorate