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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Drinking for protection? Epidemiological and experimental evidence on the beneficial effects of coffee or major coffee compounds against gastrointestinal and liver carcinogenesis

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Author(s):
Romualdo, Guilherme Ribeiro [1] ; Rocha, Ariane Bartolomeu [1] ; Vinken, Mathieu [2] ; Cogliati, Bruno [3] ; Moreno, Fernando Salvador [4] ; Garcia Chaves, Maria Angel [5] ; Barbisan, Luis Fernando [6]
Total Authors: 7
Affiliation:
[1] Sao Paulo State Univ UNESP, Sch Med, Dept Pathol, Botucatu, SP - Brazil
[2] Vrije Univ Brussel, Fac Med & Pharm, Dept Vitro Toxicol & Dermatocosmetol, Brussels - Belgium
[3] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo - Brazil
[4] Univ Sao Paulo, Fac Pharmaceut Sci, Dept Food & Expt Nutr, Sao Paulo - Brazil
[5] Univ Granada, Univ Hosp Granada, Biosanitary Res Inst Granada Ibs GRANADA, Dept Oncol, Granada - Spain
[6] Sao Paulo State Univ UNESP, Biosci Inst, Dept Morphol, Botucatu, SP - Brazil
Total Affiliations: 6
Document type: Review article
Source: Food Research International; v. 123, p. 567-589, SEP 2019.
Web of Science Citations: 1
Abstract

Recent meta-analyses indicate that coffee consumption reduces the risk for digestive tract (oral, esophageal, gastric and colorectal) and, especially, liver cancer. Coffee bean-derived beverages, as the widely-consumed espresso and ``common{''} filtered brews, present remarkable historical, cultural and economic importance globally. These drinks have rich and variable chemical composition, depending on factors that vary from ``seeding to serving{''}. The alkaloids caffeine and trigonelline, as well as the polyphenol chlorogenic acid, are some of the most important bioactive organic compounds of these beverages, displaying high levels in both espresso and common brews and/or increased bioavailability after consumption. Thus, we performed a comprehensive literature overview of current knowledge on the effects of coffee beverages and their highly bioavailable compounds, describing: 1) recent epidemiological and experimental findings highlighting the beneficial effects against gastrointestinal/liver carcinogenesis, and 2) the main molecular mechanisms in these in vitro and in vivo bioassays. Findings predominantly address the protective effects of coffee beverages and their most common/ bioavailable compounds individually on gastrointestinal and liver cancer development. Caffeine, trigonelline and chlorogenic acid modulate common molecular targets directly implicated in key cancer hallmarks, what could stimulate novel translational or population-based mechanistic investigations. (AU)

FAPESP's process: 16/12015-0 - Caffeine, Trigonelline and Chlorogenic Acid: Modulation of miRNA expression in Fibrosis-associated Hepatocarcinogenesis.
Grantee:Guilherme Ribeiro Romualdo
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/26217-7 - Action of coffee bioactive compounds towards modulation of miRNAs expression during the colon carcinogenesis in vitro and in vivo
Grantee:Ariane Rocha Bartolomeu
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 16/14420-0 - miRNA expression in Fibrosis-associated Hepatocarcinogenesis: Modulation by Caffeine, Trigonelline and Chlorogenic Acid.
Grantee:Luís Fernando Barbisan
Support type: Regular Research Grants