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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Organic-inorganic collagen/iota-carrageenan/hydroxyapatite hybrid membranes are bioactive materials for bone regeneration

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Nogueira, Lucas F. B. [1] ; Maniglia, Bianca C. [1] ; Blacido, Delia R. T. [1] ; Ramos, Ana P. [1]
Total Authors: 4
[1] Univ Sao Paulo, Dept Quim, Fac Filosofia Ciencias & Letras Ribeirao Preto, BR-14040900 Ribeirao Preto, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Journal of Applied Polymer Science; v. 136, n. 39 OCT 15 2019.
Web of Science Citations: 0

This study aimed to produce biomembranes with controlled degradability for application in bone regeneration in order to stimulate biological reactions necessary to improve bone formation. Hydrogels were prepared by dissolving hydrolyzed collagen (HC) and iota-carrageenan (iota-Carr) in aqueous mixtures containing CaCl2 and H3PO4. A rise in pH by exposure to NH3(g) caused mineral precipitation into the hydrogel. Subsequently, the membranes were fabricated by solvent casting. Infrared spectroscopy and X-ray diffraction attested hydroxyapatite formation. The crystallite size was close to 12 nm, which was smaller than the size reported for human bone apatite. The membranes induced bone-like apatite precipitation in simulated body fluid. The carrageenan content modulated the membrane mechanical behavior. Membranes with controlled degradability were obtained by using higher amount of this polysaccharide. These membranes were able to release HC in physiological conditions. The surface properties were evaluated in terms of wettability and surface energy (gamma(S)) by means of contact angle (theta(c)) measurements. Low theta(c) (8.5-16.8) indicated that the hybrid membranes were hydrophilic, while higher gamma(S) values, around 70.6 mJ.m(-2), could favor biomolecule incorporation into the surface. Our data set evidenced that these materials could potentially be used as a temporary guided tissue regeneration membrane with the possibility of inducing bone regeneration. (c) 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48004. (AU)

FAPESP's process: 15/21694-6 - Formation and characterization of bioactive membranes obtained from natural polymers reinforced with biominerals
Grantee:Lucas Fabrício Bahia Nogueira
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 17/08892-9 - Bioactive surfaces designed from Langmuir-Blodgett Films and Biominerals
Grantee:Ana Paula Ramos
Support Opportunities: Regular Research Grants
FAPESP's process: 16/25955-1 - Synthesis and characterization of hybrid biopolymer membranes containing apatites and silver nanoparticles
Grantee:Lucas Fabrício Bahia Nogueira
Support Opportunities: Scholarships in Brazil - Master