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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

High-fat diet intake induces depressive-like behavior in ovariectomized rats

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Boldarine, Valter T. [1] ; Pedroso, Amanda P. [1] ; Neto, Nelson I. P. [1] ; Dornellas, Ana P. S. [1] ; Nascimento, Claudia M. O. [1] ; Oyama, Lila M. [1] ; Ribeiro, Eliane B. [1]
Total Authors: 7
[1] Univ Fed Sao Paulo UNIFESP, Dept Physiol, Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, JUL 22 2019.
Web of Science Citations: 1

This study tested the effects of ovariectomy, allied or not to high-fat feeding and estradiol replacement, on hormonal, metabolic and behavioral parameters, to explore the connection of obesity and depression after menopause. Wistar rats were either ovariectomized or sham-operated and fed with either standard chow or lard-enriched diet for twelve weeks. Sub-groups of ovariectomized rats received estradiol replacement. Depressive-like behaviors were assessed by the forced swim test and locomotor activity was assessed by the elevated plus maze test. Ovariectomy alone increased body weight gain and feed efficiency and induced hyperleptinemia and glucose intolerance while it increased caloric intake and body adiposity only marginally. High-fat intake alone induced obesity and, in combination with ovariectomy, accentuated the ovariectomy-induced alterations. Estradiol replacement attenuated the hormonal alterations only in chow-fed rats. Ovariectomy combined with high-fat intake induced depressive-like behaviors, which were marginally attenuated by estradiol. Depressive-like behaviors were associated with metabolic and body composition parameters and with estrogen status. The data indicate that the vulnerability to develop depression after menopause is influenced by high-fat intake. It is suggested that weight management is a crucial issue in postmenopausal women, probably having a beneficial role in preventing the appearance of mental health problems. (AU)

FAPESP's process: 12/03172-4 - Obesity and depression in the post-menopause: study in rats about the effects of ovariectomy on behavioral aspects and parameters of the central regulation of feeding
Grantee:Eliane Beraldi Ribeiro
Support type: Regular Research Grants