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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

New Cyclodepsipeptide Derivatives Revealed by Genome Mining and Molecular Networking

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Paulo, Bruno S. [1] ; Sigrist, Renata [1] ; Angolini, Celio F. F. [2] ; De Oliveira, Luciana G. [1]
Total Authors: 4
[1] Univ Estadual Campinas, UNICAMP, Dept Organ Chem, Cidade Univ Zeferino Vaz S-N, POB 6154, BR-13083970 Campinas, SP - Brazil
[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci, BR-09210580 Santo Andre, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: CHEMISTRYSELECT; v. 4, n. 27, p. 7785-7790, JUL 23 2019.
Web of Science Citations: 1

Genome mining and molecular networking analyses have revealed a renewed capacity to uncover molecules and biosynthetic pathways from bacterial secondary metabolism. The present study describes the association of genome mining and molecular networking to correlate production of valinomycin cyclodepsipeptide derivatives by Streptomyces sp. CBMAI 2042. Additionally, expression of the entire gene cluster in a heterologous host successfully allowed the association of this biosynthetic assembly to the production of montanastatin, valinomycin and at least five structural analogues, revealing a plasticity of the modules and an interesting thioesterase activity capable of assembling two or three units of the tetradepsipeptide monomer. (AU)

FAPESP's process: 15/01013-4 - Mining a t1PKS-transAT PKS-NRPS in Streptomyces sp. genome
Grantee:Renata Sigrist
Support Opportunities: Scholarships in Brazil - Doctorate (Direct)
FAPESP's process: 14/12727-5 - Genome mining in Streptomyces
Grantee:Luciana Gonzaga de Oliveira
Support Opportunities: Regular Research Grants
FAPESP's process: 14/50249-8 - Green chemistry: sustainable synthetic methods employing benign solvents, safer reagents, and bio-renewable feedstock
Grantee:Arlene Gonçalves Corrêa
Support Opportunities: Research Grants - Research Centers in Engineering Program
FAPESP's process: 13/12598-8 - Mining a of t1PKS-transAT PKS-NRPS in Streptomyces sp.
Grantee:Renata Sigrist
Support Opportunities: Scholarships in Brazil - Master