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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of sleep restriction during pregnancy on lipids and glucose homeostasis of female offspring submitted to ovariectomy

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Author(s):
Argeri, Rogerio [1] ; Carvalho, Diego Soares [1, 2] ; Palma, Beatriz Duarte [3] ; Hirata, Aparecida Emiko [1] ; Gomes, Guiomar Nascimento [1]
Total Authors: 5
Affiliation:
[1] Univ Fed Sao Paulo, Dept Physiol, UNIFESP, Sao Paulo, SP - Brazil
[2] Fed Inst Educ Sci & Technol, Rondonia - Brazil
[3] Ctr Univ Sao Camilo, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF DEVELOPMENTAL ORIGINS OF HEALTH AND DISEASE; v. 10, n. 3, p. 334-337, JUN 2019.
Web of Science Citations: 0
Abstract

Sleep shortening during pregnancy may alter the mother's environment, affecting the offspring. Thus, the present study evaluated the metabolic profile of female offspring from sleep-restricted rats during the last week of pregnancy. Pregnant Wistar rats were distributed into two groups: control (C) and sleep restriction (SR). The SR was performed 20 h/day, from 14th to 20th day of pregnancy. At 2 months, half of the offspring were subjected to ovariectomy (OVX); the others, to sham surgery. Studied groups were Csham, Covx, SRsham and SRovx. Cholesterol (HDL, LDL and C-total), triglycerides (TG) and glucose and insulin tolerance tests (GTT-ITT) were evaluated at 8 months. RSsham presented higher values of TG, while SRovx presented higher TG, LDL and C-total. Basal glucose concentration was increased in SRsham and SRovx. These data suggest that SR during pregnancy may be a risk factor for the development of diseases in adult female offspring. (AU)

FAPESP's process: 13/23622-7 - Evaluation of cardiovascular and kidney functions of the offspring from rats subjected to sleep restriction during pregnancy
Grantee:Guiomar Nascimento Gomes
Support Opportunities: Regular Research Grants