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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Fluoroquinolones in Hospital Wastewater: Analytical Method, Occurrence, Treatment with Ozone and Residual Antimicrobial Activity Evaluation

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Author(s):
Rodrigues-Silva, Caio [1] ; Porto, Rafael S. [1] ; dos Santos, Sabrina G. [1] ; Schneider, Jerusa [2] ; Rath, Susanne [1]
Total Authors: 5
Affiliation:
[1] Univ Estadual Campinas, Inst Quim, Dept Quim Analit, CP 6154, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, Fac Engn Civil Arquitetura & Urbanismo, CP 6143, BR-13083889 Campinas, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: Journal of the Brazilian Chemical Society; v. 30, n. 7, p. 1447-1457, JUL 2019.
Web of Science Citations: 0
Abstract

Fluoroquinolones antimicrobials are partially excreted in natura after administration. Their occurrence was investigated in hospital raw sewage (HRS) and treated wastewater (TW) using an online solid phase extraction-ultra high-performance liquid chromatography-tandem mass spectrometry method (SPE-UHPLC-MS/MS). The analytical curves ranged from 0.25 to 46 ng mL(-1) and the matrix effect, assessed for marbofloxacin and lomefloxacin, ranged from -63 to +1%. All HRS samples contained ciprofloxacin (1-34 ng mL(-1)) and ofloxacin (0.9-27 ng mL(-1)), while norfloxacin was detected in 17% of the samples (0.8-4.4 ng mL(-1)). Only ciprofloxacin (0.5-5.6 ng mL(-1)) was detected in TW samples. The antimicrobial activity of the HRS samples for E. coli was higher than a ciprofloxacin solution of 1 mg L-1, due to the presence of other antimicrobial agents. Ozonation (10 mg O-3 L-1 min(-1); 10 min) degraded up to 84% of the fluoroquinolones and removed the antimicrobial activity of HRS samples. (AU)

FAPESP's process: 14/50951-4 - INCT 2014: Advanced Analytical Technologies
Grantee:Celio Pasquini
Support type: Research Projects - Thematic Grants
FAPESP's process: 13/09543-7 - Residues of veterinary drugs in the environment
Grantee:Susanne Rath
Support type: Research Projects - Thematic Grants
FAPESP's process: 18/03571-2 - Pharmaceuticals in the Aquatic Environment.
Grantee:Susanne Rath
Support type: Regular Research Grants