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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Photobiomodulation can improve ovarian activity in polycystic ovary syndrome-induced rats

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Alves, E. D. [1] ; Bonfa, A. L. O. [2] ; Pigatto, G. R. [2] ; Anselmo-Franci, J. A. [3] ; Achcar, J. A. [2] ; Parizotto, N. A. [4, 2, 5] ; Montrezor, L. H. [2, 6]
Total Authors: 7
[1] Univ Araraquara UNIARA, Dept Biol Sci & Hlth Biol, Araraquara, SP - Brazil
[2] QUIMMERA UNIARA, Med Chem & Regenerat Med Grp, Araraquara, SP - Brazil
[3] Univ Sao Paulo, Dept Morphol Physiol & Basic Pathol, Ribeirao Preto, SP - Brazil
[4] Univ Fed Sao Carlos, Dept Physiotherapy, Sao Carlos, SP - Brazil
[5] Univ Brasil, Biomed Engn, Sao Paulo, SP - Brazil
[6] Univ Araraquara UNIARA, Dept Biol Sci & Hlth Med, Araraquara, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Web of Science Citations: 0

Follicular cystic ovary disease is a common reproductive disorder in women and females of domestic animals, characterized by anovulation and the persistence of follicle is a common cause of reproductive failure in mammalian. Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism (HA), chronic anovulation and polycystic ovaries, and it is a common reproductive endocrine disease with clinical manifestations including hirsutism, acne, infertility and obesity that can affect 5-20% of women in their reproductive age. Photobiomodulation (PBM) has been investigated and used in clinical practice, related to biomodulatory influences on cellular functions in animals and humans, both in vivo and in vitro. In this study, we include endocrine and reproductive features in a rat model for PCOS and the effects of PBM on ovarian activities. Forty-five adult female Wistar rats PCOS-induced by a single dose of the estradiol valerate (EV) were used in the study. After the EV injection for PCO induction, rats were divided into 9 groups (n = 5/group) named C30, C45 and C60 (Control group), S30, S45 and S60 (PCO group) and L30, L45 and L60 (PCO/Laser group). The rats were irradiated with laser 3 times/week. The results shown that EV PCO-induced rats had increased body mass, reduced ovary mass, and reduced GSI. The plasma levels of P4 and T were increased, and the LH plasma level was decreased by PBM stimulation. The number of ovarian follicles and corpus luteum were increased, and the number of ovarian cysts was decreased by PBM stimulation. Thus, reproductive and endocrine characteristics were modulated by PBM. (AU)

FAPESP's process: 16/02811-4 - Laser therapy and cell therapy in rats induced to ovarian syndrome polycystic
Grantee:Luis Henrique Montrezor
Support Opportunities: Regular Research Grants