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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Evaluation of neuroglobin and cytoglobin expression in adult rats exposed to silver nanoparticles during prepubescence

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da Conceicao, Rodrigo Rodrigues [1] ; de Souza, Janaina Sena [1] ; de Oliveira, Kelen Carneiro [1] ; Romano, Renata Marino [2] ; de Barros Maciel, Rui Monteiro [1] ; Dias-da-Silva, Magnus Regios [1] ; Romano, Marco Aurelio [2] ; Chiamolera, Maria Izabel [1] ; Giannocco, Gisele [3, 1]
Total Authors: 9
[1] Univ Fed Sao Paulo UNIFESP, Dept Med, Disciplina Endocrinol Clin, Lab Endocrinol Mol & Translac, Rua Pedro Toledo 669, BR-04039032 Sao Paulo, SP - Brazil
[2] State Univ Ctr Oeste, Dept Pharm, Lab Reprod Toxicol, Rua Simeao Camargo Varela Sa 03, BR-85040080 Guarapuava, Parana - Brazil
[3] Univ Fed Sao Paulo, Dept Ciencias Biol, Diadema, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: METABOLIC BRAIN DISEASE; v. 34, n. 3, p. 705-713, JUN 2019.
Web of Science Citations: 0

Silver nanoparticles (AgNPs) are clusters of silver atoms with diameters that range from 1 to 100nm. Due to the various shapes and large surface areas, AgNPs have been employed in the food and textile industries and medical fields. Therefore, because of the widespread use of these compounds, the aim of this study was to evaluate the effect of AgNP exposure on the gene and protein expression levels of Neuroglobin (Ngb) and Cytoglobin (Cygb), in the rat cortex, hippocampus and cerebellum. Post-natal day (PND) 21 male Wistar rats were randomly divided into three groups. One group received 15g/kg body weight of AgNP by gavage another group received 30g/kg and the control group that received saline, from PND23 to PND58. On PND102 the animals were euthanized and the cortex, hippocampus and cerebellum were isolated and evaluated for gene and protein expression levels of Nbg and Cygb. The results demonstrated that the 30g/kg AgNP group displayed increased gene and protein expression of Cygb in the cortex. In the Hippocampus, AgNP exposure did not modulate gene or protein expression levels of Ngb and Cygb. In cerebellum the Ngb gene and protein expression was increased with both doses of AgNP. AgNP exposure during prepubescence can modulate the gene and protein expression levels of Ngb and Cygb in adulthood. Furthermore, the observed modulation was specific to the cerebellum, and cortex, and was dose dependent. (AU)

FAPESP's process: 13/26851-7 - In vivo study of the effects of the endocrine disruptors glyphosate and bisphenol-A on the hypothalamic-pituitary-thyroid axis
Grantee:Maria Izabel Chiamolera
Support Opportunities: Regular Research Grants