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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tumor safety and side effects of photobiomodulation therapy used for prevention and management of cancer treatment toxicities. A systematic review

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Paglioni, Mariana de Pauli [1] ; Damaceno Araujo, Anna Luiza [1] ; Aristizabal Arboleda, Lady Paola [1] ; Palmier, Natalia Rangel [1] ; Fonseca, Jessica Montenegro [1] ; Gomes-Silva, Wagner [2, 3] ; Camilo Madrid-Troconis, Cristhian [1, 4] ; Silveira, Felipe Martins [1] ; Martins, Manoela Domingues [5, 1] ; Faria, Karina Morais [2] ; Prado Ribeiro, Ana Carolina [2] ; Brandao, Thais Bianca [2] ; Lopes, Marcio Ajudarte [1] ; Paes Leme, Adriana Franco [6] ; Migliorati, Cesar Augusto [7] ; Santos-Silva, Alan Roger [1]
Total Authors: 16
[1] Univ Campinas UNICAMP, Dept Oral Diag, Piracicaba Dent Sch, Ave Limeira 901, BR-13414903 Piracicaba, SP - Brazil
[2] FMUSP, Sao Paulo State Canc Inst ICESP, Dent Oncol Serv, Sao Paulo - Brazil
[3] Nove Julho Univ, Sch Med, Sao Paulo - Brazil
[4] Corp Univ Rafael Nunez, Dent Program, Cartagena - Colombia
[5] Univ Fed Rio Grande do Sul, Dept Oral Pathol, Porto Alegre, RS - Brazil
[6] CNPEM, Brazilian Biosci Natl Lab, LNBio, Sao Paulo - Brazil
[7] Univ Florida, Coll Dent, Gainesville, FL - USA
Total Affiliations: 7
Document type: Review article
Source: Oral Oncology; v. 93, p. 21-28, JUN 2019.
Web of Science Citations: 1

Photobiomodulation therapy (PBMT), also known as low-level laser therapy (LLLT), has been increasingly used for the treatment of toxicities related to cancer treatment. One of the challenges for the universal acceptance of PBMT use in cancer patients is whether or not there is a potential for the light to stimulate the growth of residual malignant cells that evaded oncologic treatment, increasing the risk for tumor recurrences and development of a second primary tumor. Current science suggests promising effects of PBMT in the prevention and treatment of breast cancer-related lymphedema and oral mucositis, among other cancer treatment toxicities. Nevertheless, this seems to be the first systematic review to analyze the safety of the use of PBMT for the management of cancer-related toxicities. Scopus, MEDLINE/PubMed, and Embase were searched electronically. A total of 27 articles met the search criteria. Selected studies included the use of PBMT for prevention and treatment of oral mucositis, lymphedema, radiodermatitis, and peripheral neuropathy. Most studies showed that no side effects were observed with the use of PBMT. The results of this systematic review, based on current literature, suggest that the use of PBMT in the prevention and management of cancer treatment toxicities does not lead to the development of tumor safety issues. (AU)

FAPESP's process: 18/02233-6 - Oncological safety of the use of intraoral and extraoral photobiomodulation in patients with oral cavity and oropharyngeal squamous cell carcinoma
Grantee:Alan Roger dos Santos Silva
Support type: Regular Research Grants
FAPESP's process: 18/04657-8 - Salivary protein markers of radiation-related oral toxicites
Grantee:Natália Rangel Palmier
Support type: Scholarships in Brazil - Doctorate