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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Galleria mellonella as an experimental model to study human oral pathogens

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Rossoni, Rodnei Dennis [1] ; Ribeiro, Felipe de Camargo [1] ; Santana dos Santos, Hanna Flavia [1] ; dos Santos, Jessica Diane [1] ; Oliveira, Nicassia de Sousa [1] ; dos Santos Dutra, Marignes Theotonio [1] ; Biazzi de Lapena, Simone Aparecida [1] ; Junqueira, Juliana Campos [1]
Total Authors: 8
[1] Sao Paulo State Univ UNESP, Inst Sci & Technol, Dept Biosci & Oral Diag, Sao Jose Dos Campos, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: ARCHIVES OF ORAL BIOLOGY; v. 101, p. 13-22, MAY 2019.
Web of Science Citations: 3

The oral cavity is home to a microbial community of more than 800 species. This important microbiome is formed by commensal and opportunistic bacteria, fungi and viruses. Several distinct habitats within the mouth support heterogeneous microbial communities that constitute an important link between oral and general health. The use of animal models for in vivo studies in microbial pathogenicity is well established in the scientific community. Galleria mellonella as a model host has increased in use significantly in the last few years. This invertebrate model provides studies on a large scale, serving as screens for studies on vertebrate animals, such as mice and rats. In this review, different studies of microbial genera of dental importance (Enterococcus, Candida, Lactobacillus, Porphyromonas and Streptococcus) are discussed, highlighting the use of G. mellonella as a suitable model for studying pathogenesis, efficacy of antimicrobial compounds, and immune responses. (AU)

FAPESP's process: 16/25544-1 - Development of probiotic formulations for bucal candidiasis prevention: in vitro and in vivo study
Grantee:Felipe de Camargo Ribeiro
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 17/19219-3 - Identification of bioactive substances produced by Lactobacillus paracasei 28.4 for the control of oral candidiasis
Grantee:Rodnei Dennis Rossoni
Support type: Scholarships in Brazil - Post-Doctorate