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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Na+/Ca2+ exchangers: Unexploited opportunities for cancer therapy?

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Rodrigues, Tiago [1, 2] ; Nunez Estevez, Gabriela Nohemi [2] ; dos Santos Tersariol, Ivarne Luis [1, 3]
Total Authors: 3
[1] Univ Mogi Das Cruzes, Interdisciplinary Ctr Biochem Invest CIIB, Mogi Das Cruzes, SP - Brazil
[2] Fed Univ ABC UFABC, Ctr Nat & Human Sci CCNH, Santo Andre, SP - Brazil
[3] Fed Univ Sao Paulo Unifesp Sao Paulo, Sao Paulo Sch Med, Dept Biochem, Sao Paulo, SP - Brazil
Total Affiliations: 3
Document type: Review article
Source: Biochemical Pharmacology; v. 163, p. 357-361, MAY 2019.
Web of Science Citations: 1

Calcium is a well-studied ion that acts as a cofactor in several reactions and as intracellular second messenger. It plays crucial roles in living cells by regulating several processes from cell division to death. The disruption of Ca2+ homeostasis is related to cell and tissue damage and it is involved in several pathological conditions and diseases, including cancer. Tumor cells exhibit several molecular features in relation to normal cells in order to acquire proliferative and survival advantages, and Ca2+ signaling is directly or indirectly involved in these pathways. Thus, changes in the expression of Ca2+ channels and pumps are frequently described in some cancers, including transient receptor potential (TRP) family channels, store- and voltage-gated Ca2+ channels, store release channels, and Ca2+ ATPases. Although the sodium/calcium exchanger (Na+/Ca2+ exchanger; NCX) and the therapeutic potential of its inhibitors have been extensively studied in heart diseases, there are few studies about the molecular and functional aspects of NCX in cancer. Here, the current knowledge about NCX in cancer will be reviewed and possible strategies to target NCX for cancer therapy will be discussed. (AU)

FAPESP's process: 15/03964-6 - Glycosaminoglycans and proteoglycans: interplay between structure and function
Grantee:Helena Bonciani Nader
Support Opportunities: Research Projects - Thematic Grants
FAPESP's process: 16/07367-5 - Investigation of Phenothiazine-Induced Cell Death Mechanisms In Tumor Cells: Changes in Gene Expression, Role of Bcl-2 Family Proteins, and ER Stress
Grantee:Tiago Rodrigues
Support Opportunities: Regular Research Grants