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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Innovative nanocompounds for cutaneous administration of classical antifungal drugs: a systematic review

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Santos, Rafael Silva [1, 2] ; Loureiro, Kahynna Cavalcante [1, 2] ; Rezende, Polyana Santos [1, 2] ; Andrade, Luciana Nalone [1, 2] ; Barbosa, Raquel de Melo [3] ; Santini, Antonello [4] ; Santos, Ana Claudia [5, 6] ; da Silva, Classius Ferreira [7] ; Souto, Eliana Barbosa [5, 8] ; de Sousa, Damiao Pergentino [9] ; Amaral, Ricardo Guimaraes [10] ; Severino, Patricia [1, 2]
Total Authors: 12
[1] Univ Tiradentes UNIT, Aracaju - Brazil
[2] Inst Tecnol & Pesquisa, Lab Nanotecnol & Nanomed LNMed, Ave Murilo Dantas, Aracaju - Brazil
[3] Univ Fed Rio Grande do Norte, Fac Pharm, Dept Pharm, Petropolis - Brazil
[4] Univ Napoli Federico II, Dept Pharm, Naples - Italy
[5] Univ Coimbra FFUC Polo Ciencias Saude Azinhaga Sa, Fac Pharm, Dept Pharmaceut Technol, Coimbra - Portugal
[6] Inst Mol & Cell Biol, Inst Innovat & Hlth Res, Grp Genet Cognit Dysfunct, Porto - Portugal
[7] Univ Fed Sao Paulo, Biotechnol Lab Nat Prod BIONAT, Inst Environm Sci Chem & Pharmaceut, Diadema - Brazil
[8] Univ Coimbra, Fac Pharm, REQUIMTE LAQV Grp Pharmaceut Technol, Coimbra - Portugal
[9] Univ Fed Paraiba, Dept Ciencias Farm, Joao Pessoa, Paraiba - Brazil
[10] Univ Fed Sergipe, Dept Fisiol, Sao Cristovao - Brazil
Total Affiliations: 10
Document type: Review article
Web of Science Citations: 1

Nanomedicine manipulates materials at atomic, molecular, and supramolecular scale, with at least one dimension within the nanometer range, for biomedical applications. The resulting nanoparticles have been consistently shown beneficial effects for antifungal drugs delivery, overcoming the problems of low bioavailability and high toxicity of these drugs. Due to their unique features, namely the small mean particle size, nanoparticles contribute to the enhanced drug absorption and uptake by the target cells, potentiating the therapeutic drug effect. The topical route is desirable due to the adverse effects arising from oral administration. This review provides a comprehensive analysis of the use of nano compounds for the current treatment of topical fungal infections. A special emphasis is given to the employment of lipid nanoparticles, due to their recognized efficacy, versatility, and biocompatibility, attracting the major attention as novel topical nanocompounds used for the administration of antifungal drugs. (AU)

FAPESP's process: 08/00421-8 - Incorporation and immunological evaluation of tumor antigens incorporated in solid lipid nanoparticles and solid lipid nanocarriers
Grantee:Patricia Severino
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 11/20801-2 - Polymixin B load in solid lipid nanoparticles for incorporation in mucoadhesive hydrogels for oral mucositis treatment
Grantee:Patricia Severino
Support Opportunities: Scholarships in Brazil - Post-Doctoral