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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Camphor, Applied Epidermally to the Back, Causes Snout- and Chest-Grooming in Rats: A Response Mediated by Cutaneous TRP Channels

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Ishikawa, Debora T. [1] ; Lillo Vizin, Robson Cristiano [1, 2] ; de Souza, Cristiane Oliveira [1] ; Carrettiero, Daniel Carneiro [1, 3] ; Romanovsky, Andrej A. [2] ; Almeida, Maria Camila [1, 3]
Total Authors: 6
[1] Fed Univ ABC, Grad Program Neurosci & Cognit, BR-09606070 Sao Bernardo Do Campo, SP - Brazil
[2] St Josephs Hosp, Thermoregulat & System Inflammat Lab, FeverLab, Phoenix, AZ 85013 - USA
[3] Fed Univ ABC, Ctr Nat & Human Sci, BR-09606070 Sao Bernardo Do Campo, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: PHARMACEUTICALS; v. 12, n. 1 FEB 2 2019.
Web of Science Citations: 0

Thermoregulatory grooming, a behavioral defense against heat, is known to be driven by skin-temperature signals. Because at least some thermal cutaneous signals that drive heat defenses are likely to be generated by transient receptor potential (TRP) channels, we hypothesized that warmth-sensitive TRPs drive thermoregulatory grooming. Adult male Wistar rats were used. We showed that camphor, a nonselective agonist of several TRP channels, including vanilloid (V) 3, when applied epidermally to the back (500 mg/kg), caused a pronounced self-grooming response, including paw-licking and snout- and chest-{''}washing{''}. By the percentage of time spent grooming, the response was similar to the thermoregulatory grooming observed during exposure to ambient warmth (32 degrees C). Ruthenium red (a non-selective antagonist of TRP channels, including TRPV3), when administered intravenously at a dose of 0.1 mg/kg, attenuated the self-grooming behavior induced by either ambient warmth or epidermal camphor. Furthermore, the intravenous administration of AMG8432 (40 mg/kg), a relatively selective TRPV3 antagonist, also attenuated the self-grooming response to epidermal camphor. We conclude that camphor causes the self-grooming behavior by acting on TRP channels in the skin. We propose that cutaneous warmth signals mediated by TRP channels, possibly including TRPV3, drive thermoregulatory self-grooming in rats. (AU)

FAPESP's process: 13/25503-5 - Involvement of TRPM8 channels in thermoregulation of Wistar rats
Grantee:Robson Cristiano Lillo Vizin
Support type: Scholarships in Brazil - Doctorate
FAPESP's process: 15/23426-9 - Beta-amyloid in Alzheimer's Disease: death or survival? Involvement of NF-kappaB and BAG2
Grantee:Daniel Carneiro Carrettiero
Support type: Regular Research Grants
FAPESP's process: 15/02991-0 - Involvement of TRPM8 channels in thermoregulation of Wistar rats
Grantee:Maria Camila Almeida
Support type: Regular Research Grants