Advanced search
Start date
(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Hippocampal and cortical communication around micro-arousals in slow-wave sleep

Full text
dos Santos Lima, Gustavo Zampier [1, 2, 3] ; Lobao-Soares, Bruno [1] ; Corso, Gilberto [1] ; Belchior, Hindiael [4] ; Lopes, Sergio Roberto [5] ; Prado, Thiago de Lima [6] ; Nascimento, George [7] ; de Franca, Arthur Cavalcanti [8] ; Fontenele-Araujo, John [9] ; Ivanov, Plamen Ch [3, 10, 11]
Total Authors: 10
Show less -
[1] Univ Fed Rio Grande do Norte, Dept Biofis & Farmacol, Natal, RN - Brazil
[2] Univ Fed Rio Grande do Norte, Escola Ciencias & Tecnol, Natal, RN - Brazil
[3] Boston Univ, Keck Lab Network Physiol, Dept Phys, 590 Commonwealth Ave, Boston, MA 02215 - USA
[4] Univ Fed Rio Grande do Norte, Fac Ciencias Saude Trairi, Natal, RN - Brazil
[5] Univ Fed Parana, Dept Fis, Curitiba, Parana - Brazil
[6] Univ Fed Vales Jequitinhonha & Mucuri, Inst Engn Ciencia & Tecnol, Janauba, MG - Brazil
[7] Univ Fed Rio Grande do Norte, Dept Engn Biomed, Natal, RN - Brazil
[8] Univ Fed Rio Grande do Norte, Inst Cerebro, Natal, RN - Brazil
[9] Univ Fed Rio Grande do Norte, Dept Fisiol & Comportamento, Natal, RN - Brazil
[10] Div Sleep Med, Boston, MA 02115 - USA
[11] Harvard Med Sch, Brigham & Womens Hosp, Boston, MA 02115 - USA
Total Affiliations: 11
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, APR 10 2019.
Web of Science Citations: 0

Sleep plays a crucial role in the regulation of body homeostasis and rhythmicity in mammals. Recently, a specific component of the sleep structure has been proposed as part of its homeostatic mechanism, named micro-arousal. Here, we studied the unique progression of the dynamic behavior of cortical and hippocampal local field potentials (LFPs) during slow-wave sleep-related to motor-bursts (micro-arousals) in mice. Our main results comprised: (i) an abrupt drop in hippocampal LFP amplitude preceding micro-arousals which persisted until the end of motor-bursts (we defined as t interval, around 4s) and a similar, but delayed amplitude reduction in cortical (S1/M1) LFP activity occurring at micro-arousal onset; (ii) two abrupt frequency jumps in hippocampal LFP activity: from Theta (6-12 Hz) to Delta (2-4 Hz), also t seconds before the micro-arousal onset, and followed by another frequency jump from Delta to Theta range (5-7 Hz), now occurring at micro-arousal onset; (iii) a pattern of cortico-hippocampal frequency communication precedes micro-arousals: the analysis between hippocampal and cortical LFP fluctuations reveal high coherence during tau interval in a broader frequency band (2-12 Hz), while at a lower frequency band (0.5-2 Hz) the coherence reaches its maximum after the onset of micro-arousals. In conclusion, these novel findings indicate that oscillatory dynamics pattern of cortical and hippocampal LFPs preceding micro-arousals could be part of the regulatory processes in sleep architecture. (AU)

FAPESP's process: 15/23487-8 - Transitions in coupled non-stationary complex systems with minimal perturbation
Grantee:Thiago de Lima Prado
Support Opportunities: Scholarships in Brazil - Post-Doctoral