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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Understanding the role of dopamine in conditioned and unconditioned fear

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Author(s):
Brandao, Marcus L. [1] ; Coimbra, Norberto C. [2, 1, 3]
Total Authors: 2
Affiliation:
[1] INeC, Campus USP, BR-14050220 Ribeirao Preto, SP - Brazil
[2] Univ Sao Paulo, Dept Pharmacol, Lab Neuroanat & Neuropsychobiol, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
[3] Univ Sao Paulo, NAP USP Neurobiol Emot Res Ctr NuPNE, Ribeirao Preto Med Sch, BR-14049900 Ribeirao Preto, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: REVIEWS IN THE NEUROSCIENCES; v. 30, n. 3, p. 325-337, APR 2019.
Web of Science Citations: 2
Abstract

Pharmacological and molecular imaging studies in anxiety disorders have primarily focused on the serotonin system. In the meantime, dopamine has been known as the neurotransmitter of reward for 60 years, particularly for its action in the nervous terminals of the mesocorticolimbic system. Interest in the mediation by dopamine of the well-known brain aversion system has grown recently, particularly given recent evidence obtained on the role of D-2 dopamine receptors in unconditioned fear. However, it has been established that excitation of the mesocorticolimbic pathway, originating from dopaminergic (DA) neurons from the ventral tegmental area (VTA), is relevant for the development of anxiety. Among the forebrain regions innervated by this pathway, the amygdala is an essential component of the neural circuitry of conditioned fear. Current findings indicate that the dopamine D-2 receptor-signaling pathway connecting the VTA to the basolateral amygdala modulates fear and anxiety, whereas neural circuits in the midbrain tectum underlie the expression of innate fear. The A13 nucleus of the zona incerta is proposed as the origin of these DA neurons projecting to caudal structures of the brain aversion system. In this article we review data obtained in studies showing that DA receptor-mediated mechanisms on ascending or descending DA pathways play opposing roles in fear/anxiety processes. Dopamine appears to mediate conditioned fear by acting at rostral levels of the brain and regulate unconditioned fear at the mid brain level. (AU)

FAPESP's process: 16/04620-1 - Dopamine and neurokinins in the mediation of the sensorimotor gating of fear and anxiety
Grantee:Marcus Lira Brandão
Support type: Regular Research Grants