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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Influence of aversive stimulation on haloperidol-induced catalepsy in rats

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Barroca, Nayara C. B. [1, 2] ; Guarda, Mariana D. [3] ; da Silva, Naiara T. [3] ; Colombo, Ana C. [1, 2] ; Reimer, Adriano E. [1, 2] ; Brandao, Marcus L. [1, 2] ; de Oliveira, Amanda R. [1, 2, 3]
Total Authors: 7
[1] Univ Sao Paulo, Inst Neurosci & Behav INeC, Ribeirao Preto - Brazil
[2] Univ Sao Paulo, Dept Psychol, Ribeirao Preto - Brazil
[3] Fed Univ Sao Carlos UFSCar, Dept Psychol, Km 235 Washington Luis Rd, BR-13565905 Sao Carlos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Behavioural Pharmacology; v. 30, n. 2-3, SI, p. 229-238, APR 2019.
Web of Science Citations: 0

Catalepsy - an immobile state in which individuals fail to change imposed postures - can be induced by haloperidol. In rats, the pattern of haloperidol-induced catalepsy is very similar to that observed in Parkinson's disease (PD). As some PD symptoms seem to depend on the patient's emotional state, and as anxiety disorders are common in PD, it is possible that the central mechanisms regulating emotional and cataleptic states interplay. Previously, we showed that haloperidol impaired contextual-induced alarm calls in rats, without affecting footshock-evoked calls. Here, we evaluated the influence of distinct aversive stimulations on the haloperidol-induced catalepsy. First, male Wistar rats were subjected to catalepsy tests to establish a baseline state after haloperidol or saline administration. Next, distinct cohorts were exposed to open-field; elevated plus-maze; open-arm confinement; inescapable footshocks; contextual conditioned fear; or corticosterone administration. Subsequently, catalepsy tests were performed again. Haloperidol-induced catalepsy was verified in all drug-treated animals. Exposure to open-field, elevated plus-maze, open-arm confinement, footshocks, or administration of corticosterone had no significant effect on haloperidol-induced catalepsy. Contextual conditioned fear, which is supposed to promote a more intense fear, increased catalepsy over time. Our findings suggest that only specific defensive circuitries modulate the nigrostriatal system mediating the haloperidol-induced cataleptic state. (AU)

FAPESP's process: 16/04620-1 - Dopamine and neurokinins in the mediation of the sensorimotor gating of fear and anxiety
Grantee:Marcus Lira Brandão
Support Opportunities: Regular Research Grants
FAPESP's process: 16/13141-0 - 46th Annual Meeting of the Society for Neuroscience - Neuroscience 2016
Grantee:Amanda Ribeiro de Oliveira
Support Opportunities: Research Grants - Meeting - Abroad
FAPESP's process: 16/05544-7 - Influence of stressful events on the catalepsy induced by intraperitoneal administration of haloperidol in rats
Grantee:Mariana Demarchi Guarda
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 13/19280-3 - Effects of aversive stimulation on the catalepsy caused by intraperitoneal administration of haloperidol
Grantee:Nayara Cobra Barreiro Barroca
Support Opportunities: Scholarships in Brazil - Scientific Initiation