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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Immunomodulation by testosterone and corticosterone in toads: Experimental evidences from transdermal application

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Madelaire, Carla Bonetti [1] ; Cassettari, Bruna de Oliveira [1] ; Gomes, Fernando Ribeiro [1]
Total Authors: 3
[1] Univ Sao Paulo, Inst Biociencias, Dept Fisiol, Rua Matao, Trav 14 321, Cidade Univ, BR-05508090 Sao Paulo, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: General and Comparative Endocrinology; v. 273, n. SI, p. 227-235, MAR 1 2019.
Web of Science Citations: 1

Androgens and glucocorticoids play important roles in vertebrate's reproduction and display complex immunomodulatory functions that may affect survival. In anurans, testosterone and corticosterone are correlated to sexual behavior, reproduction, and immune function. Male toads (Rhinella jimi) were treated with acute doses of testosterone (T) and corticosterone (CORT) and immune variables (plasma bacterial killing ability {[}BKA], swelling after phytohemagglutinin {[}PHA] injection and the time point of maximum PHA swelling response) were measured. Transdermal T and CORT application increased androgen (T-DHT) and CORT plasma levels after 1 h of treatment, respectively, without a dose-specific effect. Transdermal T treatment did not affect BKA or PHA swelling response. Individuals treated with transdermal CORT showed an earlier maximum PHA swelling response and a tendency of lower BKA 15 h after treatment. Our results indicated that an acute experimental increase of CORT plasma levels diminished time for inflammatory resolution and suppressed non-cellular innate response. (AU)

FAPESP's process: 12/24206-4 - Sazonal relationship between reproduction, energetics and immunocompetence in toads (Rhinella jimi)from Caatinga
Grantee:Carla Bonetti Madelaire
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 13/00900-1 - Comparative study of the relationships between immunocompetence and plasmatic levels of gonadal and inter-renal steroids in toads
Grantee:Fernando Ribeiro Gomes
Support Opportunities: Regular Research Grants