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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Cholinergic Stimulation by Pyridostigmine Bromide Before Myocardial Infarction Prevent Cardiac and Autonomic Dysfunction

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Barboza, C. A. [1] ; Fukushima, A. R. [2] ; Carrozzi, N. [3] ; Machi, J. F. [4] ; Dourado, P. M. M. [5] ; Mostarda, C. T. [6] ; Irigoyen, M. C. [5] ; Nathanson, L. [4] ; Morris, M. [4] ; Caperuto, E. C. [3] ; Rodrigues, B. [1]
Total Authors: 11
[1] Univ Estadual Campinas, Sch Phys Educ, Campinas, SP - Brazil
[2] Univ Sao Paulo, Sch Vet Med & Anim Sci, Dept Pathol, Sao Paulo, SP - Brazil
[3] Sao Judas Tadeu Univ USJT, Human Movement Lab, Sao Paulo, SP - Brazil
[4] Nova Southeastern Univ, Inst Neuroimmune Med, Miami, FL - USA
[5] Univ Sao Paulo, Heart Inst InCor, Sch Med, Hypertens Unit, Sao Paulo, SP - Brazil
[6] Fed Univ Maranhao UFMA, Dept Phys Educ, Sao Luis, MA - Brazil
Total Affiliations: 6
Document type: Journal article
Source: SCIENTIFIC REPORTS; v. 9, FEB 21 2019.
Web of Science Citations: 1

Inflammatory processes and cardiovascular autonomic imbalance are very relevant characteristic of the enormous dynamic process that is a myocardial infarction (MI). In this sense, some studies are investigating pharmacological therapies using acetylcholinesterase inhibitors, such as pyridostigmine bromide (PYR), aiming to increase parasympathetic tone after MI. Here we hypothesized that the use of PYR before the MI might bring an additional positive effect to the autonomic function, and consequently, in the inflammatory response and cardiac function. The present study aimed to evaluate left ventricular function, baroreflex sensitivity, autonomic modulation, and inflammatory profile in PYR- treated rats previously to MI. Methods: Male Wistar rats (250-300 g) were treated for 60 days with PYR. After treatment, they were submitted to the MI. After the MI, the autonomic and ventricular function were evaluated, as well as the systemic, left ventricle, and adipose tissue inflammatory profile. Results: PYR, performed before MI, prevented HR increase, systolic function impairment, baroreflex sensitivity drop, as well as pulse interval variance, RMSSD, blood pressure and parasympathetic modulation reduction in treated rats compared to untreated rats. Also, this positive functional changes may have been a result of the reduced inflammatory parameters in the left ventricle (IFN-alpha, IL-6, and IL-1 beta), as well as increased IL-10 expression and IL-10/TNF-alpha ratio in treated animals before MI. Conclusion: Prior treatment with PYR prevents impairment of the autonomic nervous system after MI, which may be associated with the attenuated expression of inflammatory factors and heart dysfunction. (AU)

FAPESP's process: 13/14788-9 - Effects of exercise training and cholinergic stimulation with pyridostigmine bromide before and after myocardial infarction: role on cardiac and autonomic function, and inflammatory profile
Grantee:Bruno Rodrigues
Support Opportunities: Regular Research Grants
FAPESP's process: 14/06669-2 - Aerobic and resistance exercise training associated with cholinergic stimulation by pyridostigmine bromide previously to myocardial infarction in rats: role on cardiac and autonomic function, and in inflammatory profile
Grantee:Catarina de Andrade Barboza
Support Opportunities: Scholarships in Brazil - Doctorate