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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Transcranial direct current stimulation in children with autism spectrum disorder: a systematic scoping review

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Caldas Osorio, Ana Alexandra [1, 2] ; Brunoni, Andre Russowsky [3, 4, 5, 6, 7]
Total Authors: 2
[1] Univ Prebiteriana Mackenzie, Social & Cognit Neurosci Lab, Sao Paulo - Brazil
[2] Univ Prebiteriana Mackenzie, Dev Disorders Grad Program, Sao Paulo - Brazil
[3] Univ Sao Paulo, Univ Hosp, Sao Paulo - Brazil
[4] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Serv Interdisciplinary Neuromodulat, Sao Paulo - Brazil
[5] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Lab Neurosci, Sao Paulo - Brazil
[6] Univ Sao Paulo, Sch Med, Dept & Inst Psychiat, Natl Inst Biomarkers Neuropsychiat, Sao Paulo - Brazil
[7] Ludwig Maximilians Univ Munchen, Univ Hosp, Dept Psychiat & Psychotherapy, Munich - Germany
Total Affiliations: 7
Document type: Review article
Web of Science Citations: 0

Aim Our aim was to review available studies which test transcranial direct current stimulation (tDCS) to reduce symptom severity in children with autism spectrum disorder (ASD). Method We performed a systematic scoping review in PubMed and PsychINFO databases for studies employing tDCS in children and adolescents with ASD. Results We found five studies (two small randomized controlled studies, one experimental study, one quasi-experimental study, and one case study) reporting positive effects of tDCS in ASD symptom reduction. Study design varied greatly and sample size ranged from 1 to 20 patients. Interpretation Preliminary evidence is encouraging of the potential usefulness of tDCS for treatment of ASD in children and adolescents. It suggests tentative support for reductions in symptom severity and, according to parental reports and clinical observations, improvements in some aspects of language. However, the evidence is sparse and of low quality, so the true effect of tDCS is likely to be substantially different from the estimate of effect in this review. Therefore, future randomized controlled trials are needed to draw conclusions regarding tDCS efficacy in paediatric samples with ASD. (AU)

FAPESP's process: 14/06777-0 - Oxytocin and racial bias: impact of the intranasal administration of oxytocin on empathy to physical pain and threat perceptions in racial contexts
Grantee:Ana Alexandra Caldas Osório
Support Opportunities: Research Grants - Young Investigators Grants