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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Antimicrobial photodynamic therapy improves the alveolar repair process and prevents the occurrence of osteonecrosis of the jaws after tooth extraction in senile rats treated with zoledronate

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Author(s):
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Ervolino, Edilson [1, 2, 3] ; Statkievicz, Cristian [4] ; Toro, Luan Felipe [1, 3] ; de Mello-Neto, Joao Martins [4, 3] ; Cavazana, Thamires Priscila [5] ; Mardegan Issa, Joao Paulo [6] ; Menegati Dornelles, Rita Cassia [2] ; de Almeida, Juliano Milanezi [4] ; Hitomi Nagata, Maria Jose [4] ; Okamoto, Roberta [2, 4] ; Casatti, Claudio Aparecido [2] ; Garcia, Valdir Gouveia [4, 3] ; Theodoro, Leticia Helena [4, 3]
Total Authors: 13
Affiliation:
[1] Sao Paulo State Univ UNESP, Inst Biosci, Rua Prof Dr Antonio Celso Wagner Zanin 250, BR-18618689 Botucatu, SP - Brazil
[2] Sao Paulo State Univ UNESP, Sch Dent, Dept Basic Sci, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[3] Sao Paulo State Univ UNESP, Sch Dent, Grp Res & Study Laser Dent, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[4] Sao Paulo State Univ UNESP, Dept Surg & Integrated Clin, Sch Dent, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[5] Sao Paulo State Univ Unesp, Sch Dent, Dept Pediat Dent & Publ Hlth, Rua Jose Bonifacio 1193, BR-16015050 Aracatuba, SP - Brazil
[6] Sao Paulo Univ USP, Sch Dent, Dept Morphol Physiol & Basic Pathol, Ave Cafe S-N, BR-14040904 Ribeirao Preto, SP - Brazil
Total Affiliations: 6
Document type: Journal article
Source: BONE; v. 120, p. 101-113, MAR 2019.
Web of Science Citations: 3
Abstract

This study evaluated the effects of antimicrobial photodynamic therapy (aPDT) in the alveolar repair of rats with major risk factors for bisphosphonate-related osteonecrosis of the jaws (BRONJ). Senile rats received 0.45 ml of vehicle (VEH and VEH/aPDT) or 0.45 ml of zoledronate (ZOL and ZOL/aPDT) every three days for seven weeks. After three weeks of treatment, the first lower left molar was extracted. VEH/aPDT and ZOL/aPDT were submitted to aPDT on the extraction site at 0, 2 and 4 days postoperatively. Euthanasia was performed 28 days postoperatively and the extraction site was evaluated by clinical, histological, histometric, histochemical and immunohistochemical analysis. ZOL showed tissue repair impairment; lower percentage of newly formed bone tissue (NFBT); higher percentage of non-vital bone tissue (NVBT); fewer mature collagen fibers and increased immunolabeling for tumor necrosis factor (TNF alpha), interleukin (IL)-1 beta and IL-6. ZOL/aPDT showed clinical and histological characteristics of the extraction site, percentage of NFBT and percentage of mature collagen fiber similar to VEH. Percentage of NVBT and immunolabeling for inflammatory cytokines in ZOL/aPDT was lower than in ZOL. Immunolabeling for tartarato-resistant acid phosphatase (TRAP) was lower in ZOL and ZOL/aPDT. aPDT in the dental extraction site improves tissue repair process and prevents the occurrence of BRONJ-like lesions after tooth extraction. (AU)

FAPESP's process: 13/25367-4 - Effect of zoledronic acid during healing process of soft tissue overlying the site of tooth extraction: a study involving the main risk factors for developing osteonecrosis of the jaws
Grantee:Thamires Priscila Cavazana
Support Opportunities: Scholarships in Brazil - Scientific Initiation
FAPESP's process: 12/03067-6 - Expression of teneurins (TEN) and teneurins C-terminal associated peptides (TCAP) in the central nervous system of non-human primates (Cebus apella)
Grantee:Cláudio Aparecido Casatti
Support Opportunities: Regular Research Grants
FAPESP's process: 13/26779-4 - Effect of zoledronate during the alveolar healing process in rats: study involving the major risk factors for developing osteonecrosis of the jaws and assessment of antimicrobial photodynamic therapy (aPDT) as preventive therapy
Grantee:Edilson Ervolino
Support Opportunities: Regular Research Grants
FAPESP's process: 14/02199-1 - Evaluation of the effect of Antimicrobial Photodynamic Therapy (aPDT) during the alveolar healing process in rats that presents the major risk factors for developing osteonecrosis of the jaws associated with the use of bisphosphonates
Grantee:Cristian Statkievicz
Support Opportunities: Scholarships in Brazil - Master
FAPESP's process: 15/22395-2 - Evaluation of the effectiveness and safety of scaling and root planing for the treatment of experimental periodontitis in rats under therapy with oncologic dose of zoledronate
Grantee:Luan Felipe Toro
Support Opportunities: Scholarships in Brazil - Scientific Initiation