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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Association between col1a2 Polymorphism and the Occurrence of Pelvic Organ Prolapse in Brazilian Women

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de Freitas Rosa, Josyandra Paula [1] ; Haddad, Raphael Federicci [1] ; Reis Maeda, Fabiana Garcia [1] ; Souto, Ricardo Peres [1] ; Fernandes, Cesar Eduardo [1] ; de Oliveira, Emerson [1]
Total Authors: 6
[1] Fac Med ABC, Santo Andre, SP - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Revista Brasileira de Ginecologia e Obstetrícia; v. 41, n. 1, p. 31-36, JAN 2019.
Web of Science Citations: 0

Abstract Objective To evaluate the rs42524 polymorphism of the procollagen type I alpha (α) 2 (COL1A2) gene as a factor related to the development of pelvic organ prolapse (POP) in Brazilian women. Methods The present study involved 112 women with POP stages III and IV (case group) and 180 women with POP stages zero and I (control group). Other clinical data were obtained by interviewing the patients about their medical history, and blood was also collected from the volunteers for the extraction of genomic DNA. The promoter region of the COL1A2 gene containing the rs42524 polymorphism was amplified, and the discrimination between the G and C variants was performed by digestion of the polymerase chain reaction (PCR) products with the MspA1I enzyme followed by agarose gel electrophoresis analysis. Results A total of 292 women were analyzed. In the case group, 71 had the G/G genotype, 33 had the G/C genotype, and 7 had the C/C genotype. In turn, the ratio in the control group was 117 G/G, 51 G/C, and 11 C/C. There were no significant differences between the groups. Conclusion Our data did not show an association between the COL1A2 polymorphism and the occurrence of POP. (AU)

FAPESP's process: 14/01107-6 - Analysis of polymorphisms of genes responsible for the biosynthesis and metabolism of collagen as risk factors for development of genital prolapse
Grantee:Emerson de Oliveira
Support Opportunities: Regular Research Grants