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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Tributyrin in Inflammation: Does White Adipose Tissue Affect Colorectal Cancer?

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Biondo, Luana Amorim [1] ; Teixeira, Alexandre Abilio S. [1] ; Silveira, Loreana S. [1, 2] ; Souza, Camila O. [1] ; Costa, Raquel G. F. [1] ; Diniz, Tiego A. [1] ; Mosele, Francielle C. [1] ; Rosa Neto, Jose Cesar [1]
Total Authors: 8
[1] Univ Sao Paulo, Inst Biomed Sci, Dept Cell & Dev Biol, Av Lineu Prestes, 1524 Lab 435, BR-05508000 Sao Paulo, SP - Brazil
[2] Univ Estadual Paulista, UNESP, Postgrad Program Movement Sci, Dept Phys Educ, Exercise & Immunometab Res Grp, Rua Roberto Simonsen 305, BR-19060900 Presidente Prudente, SP - Brazil
Total Affiliations: 2
Document type: Journal article
Source: NUTRIENTS; v. 11, n. 1 JAN 2019.
Web of Science Citations: 1

Colorectal cancer affects the large intestine, leading to loss of white adipose tissue (WAT) and alterations in adipokine secretion. Lower incidence of colorectal cancer is associated with increased fibre intake. Fructooligosaccharides (FOS) are fibres that increase production of butyrate by the intestinal microbiota. Tributyrin, a prodrug of butyric acid, exerts beneficial anti-inflammatory effects on colorectal cancer. Our aim was to characterise the effects of diets rich in FOS and tributyrin within the context of a colon carcinogenesis model, and characterise possible support of tumorigenesis by WAT. C57/BL6 male mice were divided into four groups: a control group (CT) fed with chow diet and three colon carcinogenesis-induced groups fed either with chow diet (CA), tributyrin-supplemented diet (BUT), or with FOS-supplemented diet. Colon carcinogenesis decreased adipose mass in subcutaneous, epididymal, and retroperitoneal tissues, while also reducing serum glucose and leptin concentrations. However, it did not alter the concentrations of adiponectin, interleukin (IL)-6, IL-10, and tumour necrosis factor alpha (TNF)-alpha in WAT. Additionally, the supplements did not revert the colon cancer affected parameters. The BUT group exhibited even higher glucose tolerance and levels of IL-6, VEGF, and TNF-alpha in WAT. To conclude our study, FOS and butyrate supplements were not beneficial. In addition, butyrate worsened adipose tissue inflammation. (AU)

FAPESP's process: 16/06753-9 - Role of PPAR³ in the imunometabolic effects of adipose tissue and macrophages, in induced colon tumor model.
Grantee:Luana Amorim Biondo
Support Opportunities: Scholarships in Brazil - Doctorate
FAPESP's process: 16/01409-8 - The caracterization of antiinflammatory effect of palmitoleic acid suplemmentation in hepatic inflammation; The role of PPARs.
Grantee:José Cesar Rosa Neto
Support Opportunities: Regular Research Grants